| Texto completo | |
| Autor(es): |
Castro, Kelly A. D. F.
;
Moura, Nuno M. M.
;
Simoes, Mario M. Q.
;
Mesquita, Mariana M. Q.
;
Ramos, Loyanne C. B.
;
Biazzotto, Juliana C. C.
;
Cavaleiro, Jose A. S.
;
Faustino, M. Amparo F.
;
Neves, Maria Graca P. M. S.
;
da Silva, Roberto S. S.
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Molecules; v. 28, n. 12, p. 15-pg., 2023-06-01. |
| Resumo | |
Skin cancer is one of the cancers that registers the highest number of new cases annually. Among all forms of skin cancer, melanoma is the most invasive and deadliest. The resistance of this form of cancer to conventional treatments has led to the employment of alternative/complementary therapeutic approaches. Photodynamic therapy (PDT) appears to be a promising alternative to overcome the resistance of melanoma to conventional therapies. PDT is a non-invasive therapeutic procedure in which highly reactive oxygen species (ROS) are generated upon excitation of a photosensitizer (PS) when subjected to visible light of an adequate wavelength, resulting in the death of cancer cells. In this work, inspired by the efficacy of tetrapyrrolic macrocycles to act as PS against tumor cells, we report the photophysical characterization and biological assays of isobacteriochlorins and their corresponding chlorins and porphyrins against melanoma cancer cells through a photodynamic process. The non-tumoral L929 fibroblast murine cell line was used as the control. The results show that the choice of adequate tetrapyrrolic macrocycle-based PS can be modulated to improve the performance of PDT. (AU) | |
| Processo FAPESP: | 22/15336-3 - Complexos de rutênio e tratamento baseado em excitação eletrônica: uma abordagem mecanicista centrada na avaliação citotóxica por irradiação luminosa, raios-X e ultrassom em linhagens de células cancerígenas 2D e 3D |
| Beneficiário: | Roberto Santana da Silva |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 19/19448-8 - Efeito da fotobiomodulação como adendo sinergístico na foto-citotoxicidade de compostos rutênio-ftalocianinas como produtores de óxido nítrico e oxigênio singleto: avaliação bioquímica in vitro em linhagens tumorais bi- e tridimensional (3D) |
| Beneficiário: | Roberto Santana da Silva |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |