Aloe vera-loaded natural rubber latex dressing as a potential complementary treatment for psoriasis

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Herculano, Rondinelli Donizetti ; dos Santos, Thaina Oliveira ; de Barros, Natan Roberto ; Pegorin Brasil, Giovana Sant'Ana ; Scontri, Mateus ; Carvalho, Bruna Gregatti ; Mecwan, Marvin ; Farhadi, Neda ; Kawakita, Satoru ; Perego, Caio Humberto ; Carvalho, Flavio Alexandre ; dos Santos, Andre Gonzaga ; Guerra, Nayrim Brizuela ; Floriano, Juliana Ferreira ; Mussagy, Cassamo Ussemane ; Tirpakova, Zuzana ; Khorsandi, Danial ; Peirsman, Arne ; Nguyen, Huu Tuan ; Gomez, Alejandro ; Mandal, Kalpana ; de Mendonca, Ricardo Jose ; Li, Bingbing ; Dokmeci, Mehmet Remzi ; Jucaud, Vadim

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Biological Macromolecules; v. 242, p. 13-pg., 2023-05-12.

Resumo

Psoriasis is a disease that causes keratinocytes to proliferate ten times faster than normal, resulting in chronic inflammation and immune cell infiltration in the skin. Aloe vera (A. vera) creams have been used topically for treating psoriasis because they contain several antioxidant species; however, they have several limitations. Natural rubber latex (NRL) has been used as occlusive dressings to promote wound healing by stimulating cell proliferation, neoangiogenesis, and extracellular matrix formation. In this work, we developed a new A. vera- releasing NRL dressing by a solvent casting method to load A. vera into NRL. FTIR and rheological analyzes revealed no covalent interactions between A. vera and NRL in the dressing. We observed that 58.8 % of the loaded A. vera, present on the surface and inside the dressing, was released after 4 days. Biocompatibility and hemocompatibility were validated in vitro using human dermal fibroblasts and sheep blood, respectively. We observed that similar to 70 % of the free antioxidant properties of A. vera were preserved, and the total phenolic content was 2.31-fold higher than NRL alone. In summary, we combined the antipsoriatic properties of A. vera with the healing activity of NRL to generate a novel occlusive dressing that may be indicated for the management and/or treatment of psoriasis symptoms simply and economically. (AU)

• Processo FAPESP: 18/07342-8 - Desenvolvimento de dispositivos microfluídicos/órgãos em chip empregando xurografia, poliéster-toner e metacrilato de gelatina (GelMA)
• Beneficiário: Rondinelli Donizetti Herculano
• Modalidade de apoio: Bolsas no Exterior - Pesquisa
• Processo FAPESP: 17/19603-8 - Desenvolvimento de um novo adesivo à base de látex natural reforçado com barbatimão e suas frações e estudo das vias de sinalização do reparo dérmico
• Beneficiário: Rondinelli Donizetti Herculano
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 21/09207-3 - Fabricação de transistores eletroquímicos a base de melanina dopada com condutividade iônica e eletrônica melhorada
• Beneficiário: Nayrim Brizuela Guerra
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado