| Texto completo | |
| Autor(es): |
Cabral-Costa, Joao Victor
;
Kowaltowski, Alicia J.
Número total de Autores: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ESSAYS IN BIOCHEMISTRY; v. 67, n. 1, p. 13-pg., 2023-03-01. |
| Resumo | |
Astrocytes are a heterogenous population of macroglial cells spread throughout the central nervous system with diverse functions, expression signatures, and intricate morphologies. Their subcellular compartments contain a distinct range of mitochondria, with functional microdomains exhibiting widespread activities, such as controlling local metabolism and Ca2+ signaling. Ca2+ is an ion of utmost importance, both physiologically and pathologically, and participates in critical central nervous system processes, including synaptic plasticity, neuron-astrocyte integration, excitotoxicity, and mitochondrial physiology and metabolism. The mitochondrial Ca2+ handling system is formed by the mitochondrial Ca2+ uniporter complex (MCUc), which mediates Ca2+ influx, and the mitochondrial Na+/Ca2+ exchanger (NCLX), responsible for most mitochondrial Ca2+ efflux, as well as additional components, including the mitochondrial permeability transition pore (mtPTP). Over the last decades, mi-tochondrial Ca2+ handling has been shown to be key for brain homeostasis, acting centrally in physiopathological processes such as astrogliosis, astrocyte-neuron activity integration, energy metabolism control, and neurodegeneration. In this review, we discuss the current state of knowledge regarding the mitochondrial Ca2+ handling system molecular composi-tion, highlighting its impact on astrocytic homeostasis. (AU) | |
| Processo FAPESP: | 13/07937-8 - Redoxoma |
| Beneficiário: | Ohara Augusto |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |
| Processo FAPESP: | 20/06970-5 - Transportadores iônicos mitocondriais como sensores e reguladores do metabolismo energético |
| Beneficiário: | Alicia Juliana Kowaltowski |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 17/14713-0 - Ca2+ Mitocondrial no Sistema Nervoso Central e Regulação do Metabolismo Energético |
| Beneficiário: | João Victor Cabral Costa |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 19/22178-2 - NCLX na função de astrócitos: metabolismo e homeostase neuronal |
| Beneficiário: | João Victor Cabral Costa |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado |