Terbinafine Nanohybrid: Proposing a Hydrogel Carrying Nanoparticles for Topical Release

Autor(es)

Tundisi, Louise Lacalendola ; Ataide, Janaina Artem ; da Fonseca, Jessica Heline Lopes ; Silverio, Luiza Aparecida Luna ; Lancellotti, Marcelo ; Paiva-Santos, Ana Claudia ; d'Avila, Marcos Akira ; Kohane, Daniel S. ; Mazzola, Priscila Gava

• Tipo de documento: Artigo Científico
• Fonte: PHARMACEUTICS; v. 15, n. 3, p. 16-pg., 2023-03-01.

Resumo

A poloxamer 407 (P407)-Casein hydrogel was chosen to carry polycaprolactone nanoparticles carrying terbinafine (PCL-TBH-NP). In this study, terbinafine hydrochloride (TBH) was encapsulated into polycaprolactone (PCL) nanoparticles, which were further incorporated into a poloxamer-casein hydrogel in a different addition order to evaluate the effect of gel formation. Nanoparticles were prepared by the nanoprecipitation technique and characterized by evaluating their physicochemical characteristics and morphology. The nanoparticles had a mean diameter of 196.7 +/- 0.7 nm, PDI of 0.07, negative zeta potential (-0.713 mV), high encapsulation efficiency (>98%), and did not show cytotoxic effects in primary human keratinocytes. PCL-NP modulated terbinafine was released in artificial sweat. Rheological properties were analyzed by temperature sweep tests at different addition orders of nanoparticles into hydrogel formation. The rheological behavior of nanohybrid hydrogels showed the influence of TBH-PCL nanoparticles addition in the mechanical properties of the hydrogel and a long-term release of the nanoparticles from it. (AU)

• Processo FAPESP: 18/06475-4 - Desenvolvimento de formulação farmacêutica para cicatrização de queimaduras
• Beneficiário: Janaína Artem Ataide
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/10728-2 - Encapsulação e modulação de superfície com policaprolactona (PCL): uma nova abordagem para o tratamento de infecções fúngicas tópicas
• Beneficiário: Louise Lacalendola Tundisi
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/07707-6 - Desenvolvimento de forma farmacêutica para tratamento de queimaduras: analgesia, combate à infecções e cicatrização
• Beneficiário: Priscila Gava Mazzola
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/05421-8 - "Encapsulação e modulação de superfície com policaprolactona (PCL): buscando uma modificação na entrega cutânea de fármaco"
• Beneficiário: Louise Lacalendola Tundisi
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado