Comparison of Exfoliative Pap Stain and AgNOR Counts of the Tongue in Smokers and Nonsmokers

Autor(es)

Fontes, Patricia Campos ; Marques Correa, Gustavo Henrique ; Issa, Jaqueline Scholz ; Haberbeck Brandao, Adriana Aigotti ; Almeida, Janete Dias

• Tipo de documento: Artigo Científico
• Fonte: Head and Neck Pathology; v. 2, n. 3, p. 6-pg., 2008-09-01.

Resumo

Objective To compare exfoliative cytology from the oral mucosa of smokers and nonsmokers, with emphasis on proliferative activity. Methods Exfoliative cytology specimens were obtained from clinical normal mucosa from the lateral border of the tongue in 30 nonsmokers and 30 smokers ranging in age from 40 to 70 years of age, who were seen at the Heart Institute's Patient Center and the Smoking Cessation Program of the University Hospital, University of Sao Paulo Medical School (InCor-HCFMUSP). The cytologic specimens were evaluated by Papanicolaou staining and AgNOR quantification in order to evaluate the presence of cytological alterations suggestive of inflammation, dysplasia, keratinization, and proliferative activity of epithelial cells. Results Only Papanicolaou Class I and Class II smears were observed. Inflammatory alterations were found in 90% of smokers and in 87% of nonsmokers. The number of AgNORs/nucleus differed significantly between smokers and nonsmokers (3.372 +/- 0.375 versus 2.732 +/- 0.236). Conclusions Within the limitations of this research, the results indicate higher proliferative activity in smoking patients compared to nonsmoking patients, even in the absence of clinical lesions. (AU)

• Processo FAPESP: 04/10520-2 - Estudo comparativo da citologia esfoliativa da mucosa bucal de pacientes fumantes e nao-fumantes por meio da tecnica das agnors.
• Beneficiário: Gustavo Henrique Marques Correa
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica