| Texto completo | |
| Autor(es): |
Sukikara, M. H.
;
Cruz, A. M.
;
Felippe, E. C. G.
;
Anselmo-Franci, J. A.
;
Canteras, N. S.
;
de Oliveira, C. A.
;
Felicio, L. F.
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Neuroendocrinology; v. 23, n. 11, p. 5-pg., 2011-11-01. |
| Resumo | |
Opioid peptides play an important role in maternal behaviour, as well as in physiological and pathological phenomena involving motivation. Daily 3.5 mg/kg doses of morphine from days 17-21 of pregnancy are able to change the expression of maternal behaviour patterns. However, the role of hormones on such opioid behavioural actions remains to be determined. The present study investigated the endocrine responses to this morphine treatment. Corticosterone, progesterone, oestradiol and prolactin serum concentrations were measured after each morphine injection. No significant differences were found in corticosterone, oestradiol or prolactin serum concentrations. The results suggest that the treatment was unable to promote different effects, other than those caused by saline injections. In morphine-treated animals, however, progesterone concentrations were consistently and significantly increased from days 18-20 of treatment. Thus, because this behavioural meaningful opioidergic stimulation during late pregnancy affects progesterone levels, the findings of the present study raise the hypothesis that this hormone may play a role in morphine-induced changes in opioid sensitivity during late pregnancy and early lactation. (AU) | |
| Processo FAPESP: | 06/57647-2 - Relevancia neuroetologica da substancia cinzenta periaquedutal e suas implicacoes para o comportamento maternal. |
| Beneficiário: | Marcia Harumi Sukikara |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 03/00819-8 - Significado neuroetologico da participacao peptidergica no comportamento maternal. |
| Beneficiário: | Marcia Harumi Sukikara |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 10/50415-4 - Selecao comportamental durante a lactacao mediacao neural. |
| Beneficiário: | Luciano Freitas Felicio |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |