Experimental Ehrlichia canis infection changes acute-phase proteins

Autor(es)

Munhoz, Thiago Demarchi ; Maia Faria, Joice Lara ; Vargas-Hernandez, Giovanni ; Fagliari, Jose Jurandir ; Santana, Aureo Evangelista ; Machado, Rosangela Zacarias ; Tinucci-Costa, Mirela

• Tipo de documento: Artigo Científico
• Fonte: REVISTA BRASILEIRA DE PARASITOLOGIA VETERINARIA; v. 21, n. 3, p. 7-pg., 2012-07-01.

Resumo

Early diagnosis of canine ehrlichiosis favors prompt institution of treatment and improves the prognosis for the animal, since this disease causes mortality among dogs. Studies have shown that determining the concentration of acute-phase proteins (APPs) may contribute towards early detection of disease and aid in predicting the prognosis. This study aimed to evaluate the APP profile in dogs experimentally infected with Ehrlichia canis, at the start of the infection and after treatment. It also investigated whether any correlation between APP levels and the clinical and laboratory alterations over the course of the disease would be possible. The results obtained showed abnormal levels of all the APPs on the third day after infection (D3), with the highest levels being reached on D18, with the exception of ceruloplasmin and acid glycoprotein, which presented their peaks on D6 and D12 respectively. We concluded that assessment of APP levels could contribute towards establishing an early diagnosis of canine ehrlichiosis, particularly regarding acid glycoprotein and ceruloplasmin, since these proteins were detected at increased levels even before the onset of clinical and laboratory findings of the disease. (AU)

• Processo FAPESP: 07/53552-0 - Estudo das concentrações séricas da proteína C-reativa, haptoglobina e alfa ±1-glicoproteína ácida na fase aguda da infecção experimental da erliquiose canina
• Beneficiário: Thiago Demarchi Munhoz
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 07/55577-0 - Estudo de proteínas de fase aguda, da expressão gênica de citocinas e da função esplênica, de cães com erliquiose experimental em fase aguda
• Beneficiário: Mirela Tinucci Costa
• Modalidade de apoio: Auxílio à Pesquisa - Regular