| Texto completo | |
| Autor(es): |
Cavalla, Franco
;
Biguettii, Claudia Cristina
;
Colavite, Priscila Maria
;
Silveira, Elcia Varise
;
Martins, Walter, Jr.
;
Letra, Ariadne
;
Favaro Trombone, Ana Paula
;
Silva, Renato Menezes
;
Garlet, Gustavo Pompermaier
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | VIRULENCE; v. 6, n. 3, p. 12-pg., 2015-04-01. |
| Resumo | |
Th1-polarized host response, mediated by IFN-gamma, has been associated with increased severity of periodontal disease as well as control of periodontal infection. The functional polymorphism TBX21-1993T/C (rs4794067) increases the transcriptional activity of the TBX21 gene (essential for Th1 polarization) resulting in a predisposition to a Th-1 biased immune response. Thus, we conducted a case-control study, including a population of healthy controls (H, n = 218), chronic periodontitis (CP, n = 197), and chronic gingivitis patients (CG, n = 193), to investigate if genetic variations in TBX21 could impact the development of Th1 responses, and consequently influence the pattern of bacterial infection and periodontitis outcome. We observed that the polymorphic allele T was significantly enriched in the CP patients compared to CG subjects, while the H controls demonstrated and intermediate genotype. Also, investigating the putative functionality TBX21-1993T/C in the modulation of local response, we observed that the transcripts levels of T-bet, but not of IFN-gamma, were upregulated in homozygote and heterozygote polymorphic subjects. In addition, TBX21-1993T/C did not influence the pattern of bacterial infection or the clinical parameters of disease severity, being the presence/absence of red complex bacteria the main factor associated with the disease status and the subrogate variable probing depth (PD) in the logistic regression analysis. (AU) | |
| Processo FAPESP: | 14/03276-0 - Influência de polimorfismos genéticos nos padrões de colonização e recolonização bacteriana em pacientes com periodontite crônica |
| Beneficiário: | Ian Franco Cavalla Ruiz |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |