| Texto completo | |
| Autor(es): |
Delella, Flavia Karina
;
Alves de Almeida, Fernanda Losi
;
Nunes, Helga Caputo
;
Rinaldi, Jaqueline Carvalho
;
Felisbino, Sergio Luis
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Cell Biology International; v. 41, n. 11, p. 9-pg., 2017-11-01. |
| Resumo | |
Benign prostatic hyperplasia (BPH) is the most common cause of lower urinary tract symptoms (LUTS) in older men. In this regard, recent studies have attempted to define the relationships between prostatic fibrosis, LUTS, and increased expression of transforming growth factor beta 1 (TGF beta 1) in BHP. Therapeutic approaches for BPH such as 5-alpha-reductase inhibitors and alpha-adrenergic blocking agents increase TGF beta 1 expression in the prostatic tissue. Here, we investigated the effects of the 5-alpha-reductase inhibitor-finasteride-on rat ventral prostate tissue, especially with regard to the tissue distribution and gene expression of fibrillar collagens. Adult Wistar rats (n = 15) were treated with finasteride (25 mg/kg/day) by subcutaneous injection for 7 and 30 days. Age-matched, vehicle-treated (n = 15) adult Wistar rats were used as control. Finasteride treatment reduced prostate size and increased the area of types I and III collagen fibers in the prostatic stroma. As expected, TGF b1 mRNA expression was upregulated by finasteride treatment. However, COL1A1 and COL3A1 mRNA expressions decreased after both 7 and 30 days of finasteride treatment, suggesting that finasteride treatment promotes prostate parenchyma and stroma changes, which lead to the observed types I and III collagen remodeling without de novo collagen synthesis. The upregulation of TGF beta 1mRNAand protein associated with the 5-alpha-reductase inhibitor is more closely related to epithelial and stromal cell death pathways than to prostatic fibrosis. (AU) | |
| Processo FAPESP: | 08/57906-3 - Instituto Nacional de Fotônica Aplicada à Biologia Celular - INFABIC |
| Beneficiário: | Hernandes Faustino de Carvalho |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 06/60116-9 - Efeito do diabete e da reposicao com insulina sobre o processo de maturacao da prostata ventral do rato wistar: alteracoes morfologicas e na atividade de metaloproteinases de matriz mmp-2 e -9. |
| Beneficiário: | Elaine Manoela Porto |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 06/60114-6 - Efeito da finasterida e da doxazosina sobre os diferentes lobos da prostata de rato: analise ultraestrutural e da expressao dos colagenos tipo i e iii e do tgf-beta 1. |
| Beneficiário: | Flávia Karina Delella |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |