Short bowel syndrome: influence of nutritional therapy and incretin GLP1 on bone marrow adipose tissue

Autor(es)

Parreiras-e-Silva, Luciana T. ; de Araujo, Iana M. ; Elias, Jorge, Jr. ; Nogueira-Barbosa, Marcello H. ; Suen, Vivian M. M. ; Marchini, Julio S. ; Bonella, Jessica ; Nahas, Andressa K. ; Salmon, Carlos E. G. ; de Paula, Francisco J. A.

• Tipo de documento: Artigo Científico
• Fonte: Annals of the New York Academy of Sciences; v. 1415, n. 1, p. 10-pg., 2018-03-01.

Resumo

Energy deprivation leads to a decrease in white adipose tissue and bone mineral density (BMD), while simultaneously inducing the expansion of marrow adipose tissue (MAT). In short bowel syndrome (SBS), parenteral nutrition mitigates the deterioration of nutritional status, including decreases in MAT. Osteoporosis is, however, a frequent complication of SBS. The objective of our study here was to evaluate the association of fat deposit sites (subcutaneous and visceral adipose tissues: intrahepatic lipid (IHL) and MAT) and the incretin glucagon-like peptide 1 (GLP1) with BMD in individuals with SBS. MAT was negatively correlated with lumbar spine BMD in normal individuals, but not in those in the SBS group, who otherwise showed a positive correlation between MAT and GLP1. In addition, in individuals with SBS, IHL was negatively associated with lumbar spine BMD and positively associated with C-terminal telopeptide of type 1 collagen (a serum biomarker of bone turnover). Caloric maintenance in individuals with SBS, therefore, seems to positively affect the relationship between MAT and BMD, which may be modulated, at least in part, by GLP1. (AU)

• Processo FAPESP: 16/18574-1 - Aplicação da ressonância magnética para estudo quantitativo da microarquitetura óssea e sua relação com o acúmulo de gordura muscular e óssea no diabetes mellitus tipo 2
• Beneficiário: Iana Mizumukai de Araujo
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 14/15864-3 - Relação da adiposidade visceral, hepática e óssea com a densidade mineral óssea e ocorrência de fratura no Diabetes melito tipo 1
• Beneficiário: Francisco José Albuquerque de Paula
• Modalidade de apoio: Auxílio à Pesquisa - Regular