MEA Recording System Circuit Implementation

Autor(es)

Fambrini, Francisco ; Saito, Jose Hiroki ; Del Val Cura, Luis Mariano ; IEEE

• Tipo de documento: Artigo Científico
• Fonte: IECON 2017 - 43RD ANNUAL CONFERENCE OF THE IEEE INDUSTRIAL ELECTRONICS SOCIETY; v. N/A, p. 6-pg., 2017-01-01.

Resumo

This paper presents a Micro-Electrode Array (MEA) recording system with novel concept of a multiplexer coupled prior to the amplifier and filtering stages. It is described all the recording system, since the pre-amplifier, analog channel multiplexing, amplifier and filter, and AD conversion. For the AD conversion, it was used a commercial module called BeagleBoneBlack, which is an open source board, based on a 32-bit microprocessor, making it much easier to search for neuronal signals from the in-vitro culture on MEA. As result, it is presented the first one second recording data at 1 kHz frequency of Wistar rat embryo hippocampal neuron culture. One importance of such an in-vitro culture recording in human factor is in pharmacological drug tests, before its approval for medicinal use. (AU)

• Processo FAPESP: 14/50201-5 - Sistema de aquisição e registro de sinais de neurônios in vitro em matriz de microletrodos
• Beneficiário: José Hiroki Saito
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa Inovativa em Pequenas Empresas - PIPE