Atlas of Schistosoma mansoni long non-coding RNAs and their expression correlation to protein-coding genes

Autor(es)

Vasconcelos, Elton J. R. ; Mesel, Vinicius C. ; daSilva, Lucas F. ; Pires, David S. ; Lavezzo, Guilherme M. ; Pereira, Adriana S. A. ; Amaral, Murilo S. ; Verjovski-Almeida, Sergio

• Tipo de documento: Artigo Científico
• Fonte: DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION; v. N/A, p. 5-pg., 2018-07-09.

Resumo

Long non-coding RNAs (lncRNAs) have been widely discovered in several organisms with the help of high-throughput RNA sequencing. LncRNAs are over 200 nt-long transcripts that do not have protein-coding (PC) potential, having been reported in model organisms to act mainly on the overall control of PC gene expression. Little is known about the functionality of lncRNAs in evolutionarily ancient non-model metazoan organisms, like Schistosoma mansoni, the parasite that causes schistosomiasis, one of the most prevalent infectious-parasitic diseases worldwide. In a recent transcriptomics effort, we identified thousands of S. mansoni lncRNAs predicted to be functional along the course of parasite development. Here, we present an online catalog of each of the S. mansoni lncRNAs whose expression is correlated to PC genes along the parasite lifecycle, which can be conveniently browsed and downloaded through a new web resource http://verjolab.usp.br. We also provide access now to navigation on the co-expression networks disclosed in our previous publication, where we correlated mRNAs and lncRNAs transcriptional patterns across five life-cycle stages/forms, pinpointing biological processes where lncRNAs might act upon. (AU)

• Processo FAPESP: 16/10046-6 - Efeito de GSK343, um inibidor da histona metiltransferase EZH2, sobre o parasita Schistosoma mansoni
• Beneficiário: Adriana Silva Andrade Pereira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/24560-8 - Identificação e caracterização de longos RNAs não-codificadores regulatórios no genoma de Schistosoma mansoni por meio de estratégias NGS e enfoque de sistemas
• Beneficiário: Elton José Rosas de Vasconcelos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado