| Texto completo | |
| Autor(es): |
Calvo, Adriana Maria
;
Zupelari-Goncalves, Paulo
;
Dionisio, Thiago Jose
;
Brozoski, Daniel Thomas
;
Faria, Flavio Augusto
;
Santos, Carlos Ferreira
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF PAIN RESEARCH; v. 10, p. 9-pg., 2017-01-01. |
| Resumo | |
Objective: Nonsteroidal anti-inflammatory drugs (NSAIDs) are metabolized by the cytochrome P450 enzymes (CYPs), predominantly CYP2C8 and CYP2C9. The aim of this study was to evaluate the possible association of polymorphisms in the CYP2C8*3 and CYP2C9 genes with the clinical efficacy of oral piroxicam (20 mg daily for 4 days) after lower third molar surgeries with regard to postoperative pain, swelling, trismus, adverse reactions, need for rescue medication and the volunteer's overall satisfaction. Materials and methods: For this purpose, 102 volunteers were genotyped for CYP2C8*3 and CYP2C9 polymorphisms. Briefly, genomic DNA was isolated from saliva collected from volunteers subjected to invasive lower third molar surgeries, and the preoperative, intraoperative and postoperative parameters were collected and analyzed. Results: An equal amount of piroxicam sufficiently managed postoperative pain and inflammatory symptoms, with visual analog pain scores typically < 40 mm for all genotypes investigated. Furthermore, only two out of 102 volunteers heterozygous for CYP2C8*3 and CYP2C9*3 reported adverse side effects. Conclusion: In general, slow metabolizers of piroxicam, who were volunteers with mutant alleles, were indifferent from normal metabolizers with the wild-type alleles and therefore did not require specialized piroxicam doses to manage postoperative pain and inflammation. (AU) | |
| Processo FAPESP: | 14/17803-1 - Influência do genótipo do Citocromo P450 (CYP2C9) na eficácia clínica e farmacocinética do Piroxicam após cirurgias de terceiros molares inferiores |
| Beneficiário: | Carlos Ferreira dos Santos |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 09/17851-8 - Influência do genótipo do citocromo P450 (CYP2C9) na eficácia clínica e farmacocinética do piroxicam após cirurgias de terceiros molares inferiores |
| Beneficiário: | Adriana Maria Calvo |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |