Thermographic analysis of photodynamic therapy with intense pulsed light and needle-free injection photosensitizer delivery: an animal study

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Requena, Michelle B. ; Stringasci, Mirian D. ; Pratavieira, Sebastiao ; Vollet-Filho, Jose Dirceu ; de Nardi, Andrigo B. ; Escobar, Andre ; da Rocha, Rozana W. ; Bagnato, Vanderlei S. ; de Menezes, Priscila F. C. ; Alfano, RR ; Demos, SG

• Tipo de documento: Artigo Científico
• Fonte: OPTICAL BIOPSY XVI: TOWARD REAL-TIME SPECTROSCOPIC IMAGING AND DIAGNOSIS; v. 10489, p. 9-pg., 2018-01-01.

Resumo

The photodynamic therapy (PDT) is a therapeutic modality that depends mostly on photosensitizer (PS), light and molecular oxygen species. However, there are still technical limitations in clinical PDT that are under constant development, particularly concerning PS and light delivery. Intense Pulsed Light (IPL) sources are systems able to generate pulses of high energy with polychromatic light. IPL is a technique mainly used in the cosmetic area to perform various skin treatments for therapeutic and aesthetic applications. The goals of this study were to determine temperature variance during the application of IPL in porcine skin model, and the PDT effects using this light source with PS delivery by a commercial high pressure, needle-free injection system. The PSs tested were Indocyanine Green (ICG) and Photodithazine (PDZ), and the results showed an increase bellow 10 degrees C in the skin surface using a thermographic camera to measure. In conclusion, our preliminary study demonstrated that IPL associated with needle-free injection PS delivery could be a promising alternative to PDT. (AU)

• Processo FAPESP: 09/54035-4 - EMU: facility para estudos avançados de materiais nanoestruturados e biossistemas / FAMA
• Beneficiário: Igor Polikarpov
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
• Processo FAPESP: 13/07276-1 - CEPOF - Centro de Pesquisa em Óptica e Fotônica
• Beneficiário: Vanderlei Salvador Bagnato
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 14/50857-8 - INCT 2014 - de Óptica Básica e Aplicada às Ciências da Vida
• Beneficiário: Vanderlei Salvador Bagnato
• Modalidade de apoio: Auxílio à Pesquisa - Temático