| Texto completo | |
| Autor(es): |
Velloso, Fernando J.
;
Trombetta-Lima, Marina
;
Anschau, Valesca
;
Sogayar, Mari C.
;
Correa, Ricardo G.
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BIOSCIENCE REPORTS; v. 39, p. 21-pg., 2019-04-30. |
| Resumo | |
Innate immunity comprises several inflammation-related modulatory pathways which receive signals from an array of membrane-bound and cytoplasmic pattern recognition receptors (PRRs). The NLRs (NACHT (NAIP (neuronal apoptosis inhibitor protein), C2TA (MHC class 2 transcription activator), HET-E (incompatibility locus protein from Podospora anserina) and TP1 (telomerase-associated protein) and Leucine-Rich Repeat (LRR) domain containing proteins) relate to a large family of cytosolic innate receptors, involved in detection of intracellular pathogens and endogenous byproducts of tissue injury. These receptors may recognize pathogen-associated molecular patterns (PAMPs) and/or danger-associated molecular patterns (DAMPs), activating host responses against pathogen infection and cellular stress. NLR-driven downstream signals trigger a number of signaling circuitries, which may either initiate the formation of inflammasomes and/or activate nuclear factor kappa B (NF-kappa B), stress kinases, interferon response factors (IRFs), inflammatory caspases and autophagy. Disruption of those signals may lead to a number of pro-inflammatory conditions, eventually promoting the onset of human malignancies. In this review, we describe the structures and functions of the most well-defined NLR proteins and highlight their association and biological impact on a diverse number of cancers. (AU) | |
| Processo FAPESP: | 16/05311-2 - Medicina regenerativa visando à terapia de doenças crônico-degenerativas (câncer e diabetes) |
| Beneficiário: | Mari Cleide Sogayar |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |