Carbon black-chitosan film-based electrochemical sensor for losartan

Autor(es)

Silva, Lais Pereira ; Silva, Tiago Almeida ; Moraes, Fernando Cruz ; Fatibello-Filho, Orlando

• Tipo de documento: Artigo Científico
• Fonte: Journal of Solid State Electrochemistry; v. 24, n. 8, p. 8-pg., 2020-05-20.

Resumo

A novel electrochemical method for determination of losartan using a glassy carbon electrode modified with carbon black nanoparticles immobilized within a crosslinked chitosan film is proposed. The electrochemical behavior of losartan was investigated using cyclic voltammetry, which presented an irreversible oxidation peak at a potential of + 1.28 V vs. Ag/AgCl (3.0 mol L-1 KCl). The electroactivity of losartan on the modified electrode was significantly improved in terms of peak potential and peak current intensity comparatively to bare working electrode. Using square-wave voltammetry technique under optimized conditions, the modified electrode showed a linear response in the concentration range of 4.97 to 47.6 mu mol L-1 with a limit of detection of 0.479 mu mol L-1. The developed electrochemical method was successfully applied for the determination of losartan in pharmaceutical formulation samples, with results consistent with those obtained by a comparative UV-Vis spectrophotometric method at 95% confidence level. In addition, losartan quantification was also achieved at synthetic biological fluid samples. (AU)

• Processo FAPESP: 17/10118-0 - Estudo e aplicação da tecnologia eletroquímica para a análise e a degradação de interferentes endócrinos: materiais, sensores, processos e divulgação científica
• Beneficiário: Marcos Roberto de Vasconcelos Lanza
• Modalidade de apoio: Auxílio à Pesquisa - Temático