Bixa orellanaL. by-products' fractions from an industrial process: antiproliferative activity on tumor cells and chemical profile

Autor(es)

Basting, Rosanna Tarkanyi ; Barreto de Abreu, Pedro Manoel ; Sousa, Ilza Maria de Oliveira ; de Carvalho, Joao Ernesto ; Carvalho, Paulo Roberto Nogueira ; Foglio, Mary Ann

• Tipo de documento: Artigo Científico
• Fonte: NATURAL PRODUCT RESEARCH; v. 35, n. 24, p. 6-pg., 2020-10-01.

Resumo

This study evaluated the phytochemical characterization ofBixa orellana(BO extract) unsaponifiable extract and resulting fractions (F fraction - FF, Geranyl fraction - GF and R fraction- RF) obtained as by-products of an industrial process investigatingin vitroantiproliferative activities in human tumoral cells. The main compounds identified by GC-MS for BO extract were Geranylgeraniol (61.51%); for FF: Geranylgeraniol (70.23%); for GF: Geranylgeraniol (78.92%) and for RF:beta-cubebene (27.75%). Quantifications of geranylgeraniol by GC-FID presented the percentage content: BO 27.52%; FF 38.52%; GF 51.44% and RF 1.81%. BO extract showed a significant antiproliferative activity, with GI(50)up to 4 mu g/mL. All fractions had a remarkably similar antiproliferative activity profile (GI(50)27-47 mu g/mL). Data reported herein showed an important cytostatic effect for BO extract, nevertheless this activity is not attributed exclusively to geranylgeraniol. In conclusion, this by-product becomes of great value, being a potential candidate for development of new anti-tumor ingredients. (AU)

• Processo FAPESP: 15/08600-2 - Pterodon pubescens Benth. e Cordia verbenacea DC: avaliação do efeito sinérgico na atividade anti-inflamatória e estudos de mecanismos de ação e sinalização celular
• Beneficiário: Rosanna Tarkany Basting
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 18/20252-8 - Avaliação da associação de extratos de frutos de Pterodon pubescens Benth., Arrabidaea chica Verlot e Bixa orellana nas atividades cicatrizantes, antinociceptiva e anti-inflamatória
• Beneficiário: Mary Ann Foglio
• Modalidade de apoio: Auxílio à Pesquisa - Regular