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Fim Neto, Arnaldo ; De Luccas, Julia Baldi ; Bianquenti, Bruno Leonardo ; Almeida, Tiago Paggi ; Rocha, Maria Sheila ; Yoneyama, Takashi ; Franceschi Godinho, Fabio Luiz ; Soriano, Diogo Coutinho ; Diaz, CAG ; Gonzalez, CC ; Leber, EL ; Velez, HA ; Puente, NP ; Flores, DL ; Andrade, AO ; Galvan, HA ; Martinez, F ; Garcia, R ; Trujillo, CJ ; Mejia, AR

• Tipo de documento: Artigo Científico
• Fonte: VIII LATIN AMERICAN CONFERENCE ON BIOMEDICAL ENGINEERING AND XLII NATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING; v. 75, p. 6-pg., 2020-01-01.

Resumo

Parkinson's disease (PD) has a high impact on motor and cognitive impairment. Recent studies have suggested that abnormal beta band activity (13-35 Hz) in local field potentials (LFP) within the Subthalamic Nucleus (STN) are associated with PD's symptoms. Moreover, these oscillations are characterized by non-stationary behavior throughout the LFP defined as beta bursts. Despite of the currently widespread framework for evaluating beta bursts based on Continuous Wavelet Transform (CWT) coefficients, a carefully methodological investigation is required, especially when dealing with shorter intraoperative recordings in the context of deep brain stimulation (DBS). Aiming to investigate methodological dependence in beta burst detection, this work presents a comparison between wavelets analysis vs. Hilbert Transform (HT) magnitude for beta bursts duration evaluation considering different percentiles thresholds. Signals from 17 hemispheres of 12 tremor dominant PD patients undergoing stereotaxic surgery under rest and movement conditions were investigated. Bursts durations evaluated by both methods were capable of detecting significant differences between rest vs. movement conditions, depending on the adopted percentile threshold. These results point to a better comprehension of beta burst activity under daily motor tasks as also reveals a methodological dependence on burst characterization, being the HT method more prone to detect beta bursts with shorter durations in contrast to CWT. (AU)

• Processo FAPESP: 18/14283-8 - Características espectrais de potenciais de campo local registrados em núcleo subtalâmico de pacientes com Doença de Parkinson
• Beneficiário: Bruno Leonardo Bianqueti
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 18/14285-0 - Diferenças espectrais dos potenciais de campo local registrados em núcleos subtalâmicos bilaterais de pacientes com Doença de Parkinson
• Beneficiário: Julia Baldi de Luccas
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 13/07559-3 - Instituto Brasileiro de Neurociência e Neurotecnologia - BRAINN
• Beneficiário: Fernando Cendes
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 17/00319-8 - Identificação do substrato atrial em pacientes com fibrilação atrial crônica utilizando modelos estatísticos multivariados e múltiplos atributos de eletrogramas atriais
• Beneficiário: Tiago Paggi de Almeida
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado