| Texto completo | |
| Autor(es): |
Vasques, Ana Maria Veiga
;
da Silva, Ana Claudia Rodrigues
;
Bueno, Carlos Roberto Emerenciano
;
Duarte, Marco Antonio Hungaro
;
Ervolino, Edilson
;
Cintra, Luciano Tavares Angelo
;
Dezan Jr, Eloi
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF ENDODONTICS; v. 50, n. 4, p. 6-pg., 2024-03-26. |
| Resumo | |
Introduction: This study evaluated the effects of cigarette smoke inhalation (CSI) on apical periodontitis (AP) induced in rats by histometric, immunohistochemical, and microtomographic analysis. Methods: A total of 32 male Wistar rats were divided into 4 experimental groups ( n = 8): control, CSI, AP, and CSI + AP. Rats in the CSI and CSI + AP groups inhaled cigarette smoke by remaining inside a smoking chamber for 8 minutes 3 times a day for 50 days. After 20 days of smoke inhalation, rats in the AP and CSI + AP groups had the pulp of their first right lower molar exposed to induce AP. Blood was collected on day 50 to evaluate nicotine and serum cotinine levels. The animals ' mandibles were removed for histologic processing to evaluate bone resorption by histometric, immunohistochemical (receptor activator of nuclear factor kappa B ligand/osteoprotegerin), and microtomographic analysis. The Student t test was applied. Results: Histometric analysis showed a larger area of bone resorption ( P < .05) and microtomographic analysis found greater resorption volume ( P < .001) for the CSI + AP group compared with the AP group. The CSI + AP group presented a high RANKL immunostaining pattern compared with the AP group ( P < .001). Conclusions: CSI increased bone resorption caused by AP. (AU) | |
| Processo FAPESP: | 20/06310-5 - Influência da inalação de fumaça de cigarro no desenvolvimento da periodontite apical: análise do perfil inflamatório local e sistêmico em ratos Wistar |
| Beneficiário: | Eloi Dezan Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |