The therapeutic potential of reduced graphene oxide in attenuating cuprizone-induced demyelination in mice

Autor(es)

Rizoli, Cintia ; dos Santos, Nathalia Medina ; Marostica Junior, Mario Roberto ; da Cruz-Hofling, Maria Alice ; Mendonca, Monique Culturato Padilha ; de Jesus, Marcelo Bispo

• Tipo de documento: Artigo Científico
• Fonte: Nanotechnology; v. 36, n. 2, p. 12-pg., 2025-01-13.

Resumo

Reduced graphene oxide (rGO) has unique physicochemical properties that make it suitable for therapeutic applications in neurodegenerative scenarios. This study investigates the therapeutic potential of rGO in a cuprizone-induced demyelination model in mice through histomorphological techniques and analysis of biochemical parameters. We demonstrate that daily intraperitoneal administration of rGO (1 mg ml-1) for 21 days tends to reduce demyelination in the Corpus callosum by decreasing glial cell recruitment during the repair mechanism. Additionally, rGO interferes with oxidative stress markers in the brain and liver indicating potential neuroprotective effects in the central nervous system. No significant damage to vital organs was observed, suggesting that multiple doses could be used safely. However, further long-term investigations are needed to understand rGO distribution, metabolism, routes of action and associated challenges in central neurodegenerative therapies. Overall, these findings contribute to the comprehension of rGO effects in vivo, paving the way for possible future clinical research. (AU)

• Processo FAPESP: 23/06143-0 - Aspectos moleculares da interação nanopartículas e células: atividade terapêutica, entrega de oligonucleotídeos e nanotoxicidade
• Beneficiário: Marcelo Bispo de Jesus
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 20/01218-3 - Nanotoxicidade analisada individualmente através de perfil multiparamétrico baseada em imagem
• Beneficiário: Marcelo Bispo de Jesus
• Modalidade de apoio: Auxílio à Pesquisa - Regular