Autor(es)

da Silva, Aternoskaires S. R. ; Fernandes, Cassia C. ; dos Santos, Daiane A. ; Mazza, Marya C. M. ; Silva, Jackson B. A. ; Magalhaes, Lizandra G. ; Pires, Regina H. ; Miranda, Mayker L. D. ; Crotti, Antonio E. M.

• Tipo de documento: Artigo Científico
• Fonte: CHEMISTRY & BIODIVERSITY; v. 21, n. 9, p. 7-pg., 2024-08-08.

Resumo

This study reports on the chemical composition and antileishmanial and anticandidal activities of volatile oils (VOs) of Schinus molle dried leaves (SM), Cinnamomum cassia branch bark (CC) and their blends. Major constituents of SM were spathulenol (26.93 %), beta-caryophyllene (19.90 %), and caryophyllene oxide (12.69 %), whereas (E)-cinnamaldehyde (60.11 %), cinnamyl acetate (20.90 %) and cis-2-methoxycinnamic acid (10.37 %) were predominant in CC. SM (IC50=21.45 mu g/mL) and CC (IC50=23.27 mu g/mL) displayed good activity against L. amazonensis promastigotes, besides having good or moderate activity against nine Candida strains, with Minimum Inhibitory Concentration (MIC) values ranging from 31.25 to 250 mu g/mL. While the three SM and CC blends were not more active than the VOs tested individually, they exhibited remarkably high antileishmanial activity, with IC50 values ranging between 3.12 and 7.04 mu g/mL, which is very similar to the IC50 of amphotericin B (positive control). (AU)

• Processo FAPESP: 07/54241-8 - Prospecção de óleos essenciais de espécies brasileiras cultiváveis com atividade contra patógenos da cavidade bucal
• Beneficiário: Antônio Eduardo Miller Crotti
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Jovens Pesquisadores