Autor(es)

Carvalho Reis, Ana Paula ; Correia, Franciele Fernandes ; Jesus, Thais Martins ; Pagliari, Carla ; Sakai-Valente, Neusa Y. ; Belda Junior, Walter ; Criado, Paulo Ricardo ; Benard, Gil ; Teixeira Sousa, Maria Gloria

• Tipo de documento: Artigo Científico
• Fonte: Revista do Instituto de Medicina Tropical de São Paulo; v. 61, p. 6-pg., 2019-01-01.

Resumo

Dermatophytosis is a cutaneous mycosis caused by a plethora of keratinophilic fungi, but Trichophyton rubrum is the most common etiological agent. Despite its high prevalence worldwide, little is known about the host defense mechanisms in this infection, particularly the in situ immune response. Using an immunohistochemistry approach, we investigated the density of CD1a+, factor XIIIa+ and CD68+ cells in the skin of dermatophytosis patients. Langerhans cells (CD1a+ cells) were significantly decreased in the epidermis of patients, both in affected and unaffected areas. In the dermis, however, no differences in the density of macrophages (CD68+ cells) and dermal dendrocytes (factor XIIIa+ cells) were observed. These results suggest that the decreased number of Langerhans cells may be a risk factor for development of dermatophytosis. (AU)

• Processo FAPESP: 17/26208-8 - Dermatofitose crônica disseminada por Trichophyton rubrum: papel dos neutrófilos nos mecanismos efetores e na modulação da resposta adaptativa na infecção humana
• Beneficiário: Maria da Gloria Sousa Stafocker
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 18/24175-8 - Resposta imune in situ na dermatofitose crônica disseminada humana: participação dos receptores de lectina do tipo c
• Beneficiário: Ana Paula Carvalho dos Reis
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica