| Texto completo | |
| Autor(es): |
Rossi, Suelen Andreia
;
Garcia-Barbazan, Irene
;
Chamorro-Herrero, Irene
;
Taborda, Carlos Pelleschi
;
Zaragoza, Oscar
;
Zambrano, Alberto
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Microbes and Infection; v. 26, n. 3, p. 9-pg., 2024-03-16. |
| Resumo | |
Organoids can meet the needs between the use of cell culture and in vivo work, bringing together aspects of multicellular tissues, providing a more similar in vitro system for the study of various components, including host-interactions with pathogens and drug response. Organoids are structures that resemble organs in vivo , originating from pluripotent stem cells (PSCs) or adult stem cells (ASCs). There is great interest in deepening the understanding of the use of this technology to produce information about fungal infections and their treatments. This work aims the use 2D human lung organoid derived from human embryonic stem cells (hESCs), to investigate Cryptococcus neoformans -host interactions. C. neoformans is an opportunistic fungus acquired by inhalation that causes systemic mycosis mainly in immunocompromised individuals. Our work highlights the suitability of human minilungs for the study of C. neoformans infection (adhesion, invasion and replication), the interaction with the surfactant and induction of the host's alveolar pro-in flammatory response. (c) 2023 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved. (AU) | |
| Processo FAPESP: | 16/08730-6 - Patogenicidade fúngica: efeito do tabagismo, resposta imune e a modulação vacinal na paracoccidioidomicose e na histoplasmose |
| Beneficiário: | Carlos Pelleschi Taborda |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 20/09919-0 - Produção e avaliação do uso de organoide pulmonar 2D e 3D na interação patógeno hospedeiro e análise do efeito de nanopartículas de quitosana |
| Beneficiário: | Suélen Andreia Rossi |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado |