Busca avançada
Ano de início
Entree


Physical Exercise and Tumor Energy Metabolism

Texto completo
Autor(es):
Vulczak, Anderson ; Alberici, Luciane Carla
Número total de Autores: 2
Tipo de documento: Artigo Científico
Fonte: CANCER TREATMENT AND RESEARCH COMMUNICATIONS; v. 32, p. 5-pg., 2022-01-01.
Resumo

Evidence supports the antitumoral effects of physical activity, either in experimental animal models or humans. However, the biological mechanisms by which physical exercise modulates tumoral development are still unclear. An important feature of the tumor cells is the altered energy metabolism, often associated with definitions of tumor aggressiveness. Nevertheless, exercise can cause global metabolic changes in the body, as well as modulate tumor metabolism. Here we specifically discuss the metabolic changes found in tumors and how exercise can contribute to anti-tumoral effects by modulating the mitochondrial function, and tricarboxylic acid cycle-related metabolites of cancer cells. The effect of physical exercise on tumor metabolism is a new possibility for comprehension of cancer biology and developing therapies focused on tumor energy metabolism. (AU)

Processo FAPESP: 16/23509-4 - Identificação de miocinas neuroprotetoras liberadas pelo músculo esquelético humano em contração de baixa e alta intensidades: papel da bioenergética mitocondrial e do estresse oxidativo
Beneficiário:Luciane Carla Alberici
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 18/10089-2 - Controle neural, hormonal e nutricional da autofagia
Beneficiário:Isis Do Carmo Kettelhut
Modalidade de apoio: Auxílio à Pesquisa - Temático