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Metabolomics approach to understand molecular mechanisms involved in fungal pathogen-citrus pathosystems

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Autor(es):
Silva, Evandro ; Dantas, Rodolfo ; Barbosa, Julio Cesar ; Berlinck, Roberto G. S. ; Fill, Taicia
Número total de Autores: 5
Tipo de documento: Artigo Científico
Fonte: MOLECULAR OMICS; v. 20, n. 3, p. 15-pg., 2024-01-26.
Resumo

Citrus is a crucial crop with a significant economic impact globally. However, postharvest decay caused by fungal pathogens poses a considerable threat, leading to substantial financial losses. Penicillium digitatum, Penicillium italicum, Geotrichum citri-aurantii and Phyllosticta citricarpa are the main fungal pathogens, causing green mold, blue mold, sour rot and citrus black spot diseases, respectively. The use of chemical fungicides as a control strategy in citrus raises concerns about food and environmental safety. Therefore, understanding the molecular basis of host-pathogen interactions is essential to find safer alternatives. This review highlights the potential of the metabolomics approach in the search for bioactive compounds involved in the pathogen-citrus interaction, and how the integration of metabolomics and genomics contributes to the understanding of secondary metabolites associated with fungal virulence and the fungal infection mechanisms. Our goal is to provide a pipeline combining metabolomics and genomics that can effectively guide researchers to perform studies aiming to contribute to the understanding of the fundamental chemical and biochemical aspects of pathogen-host interactions, in order to effectively develop new alternatives for fungal diseases in citrus cultivation. We intend to inspire the scientific community to question unexplored biological systems, and to employ diverse analytical approaches and metabolomics techniques to address outstanding questions about the non-studied pathosystems from a chemical biology perspective. This review article communicates the integration of metabolomics and genomics approaches to unravel the citrus host-pathogen interaction. (AU)

Processo FAPESP: 23/03831-2 - Decifrando o papel dos metabólitos secundários na interação química entre fitopatógenos e o hospedeiro cítrico
Beneficiário:Evandro Aparecido da Silva
Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
Processo FAPESP: 23/06874-4 - Decifrando o papel de metabólitos secundários na interação química entre fitopatógenos e o hospedeiro citros
Beneficiário:Júlio César Jerônimo Barbosa
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 19/17721-9 - A função da Química na adaptação de holobiontes
Beneficiário:Roberto Gomes de Souza Berlinck
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 22/02992-0 - Decifrando o papel de metabólitos secundários na interação química entre fitopatógenos e o hospedeiro citros
Beneficiário:Taicia Pacheco Fill
Modalidade de apoio: Auxílio à Pesquisa - Projeto Inicial
Processo FAPESP: 22/03594-8 - Compreendendo a guerra química e as estratégias de virulência de Penicillium digitatum envolvidas na interação patógeno-hospedeiro
Beneficiário:Evandro Aparecido da Silva
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado