Imaging neuroinflammation in individuals with substance use disorders

Autor(es)

Li, Xinyi ; Ramos-Rolon, Astrid P. ; Kass, Gabriel ; Pereira-Rufino, Lais S. ; Shifman, Naomi ; Shi, Zhenhao ; Volkow, Nora D. ; Wiers, Corinde E.

• Tipo de documento: Artigo Científico
• Fonte: Journal of Clinical Investigation; v. 134, n. 11, p. 16-pg., 2024-06-03.

Resumo

Increasing evidence suggests a role of neuroinflammation in substance use disorders (SUDs). This Review presents findings from neuroimaging studies assessing brain markers of inflammation in vivo in individuals with SUDs. Most studies investigated the translocator protein 18 kDa (TSPO) using PET; neuroimmune markers myo-inositol, choline-containing compounds, and N -acetyl aspartate using magnetic resonance spectroscopy; and fractional anisotropy using MRI. Study findings have contributed to a greater understanding of neuroimmune function in the pathophysiology of SUDs, including its temporal dynamics (i.e., acute versus chronic substance use) and new targets for SUD treatment. (AU)

• Processo FAPESP: 21/13092-7 - Análise do padrão de metilação e das alterações morfofuncionais em redes neurais de controle da tomada de decisão em indivíduos com transtorno por uso do álcool
• Beneficiário: Laís da Silva Pereira Rufino
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado