Antitrypanosomal activity of new alkoxyhydroperoxides formed by cycloaddition of ozone into allyl moiety of eugenol

Autor(es)

Accioly Jr, Marcos ; Ribeiro, Fernanda S. ; Amaral, Maiara ; Levatti, Erica V. C. ; Tempone, Andre G. ; Lago, Joao Henrique G. ; Uemi, Miriam

• Tipo de documento: Artigo Científico
• Fonte: Tetrahedron; v. 159, p. 6-pg., 2024-05-08.

Resumo

Eugenol, a natural phenylpropanoid found in several plants, was exposed to ozone atmosphere to afford three new alkoxyhydroperoxides and prevised homovanillin. The effect of these compounds against the protozoan parasite Trypanosoma cruzi resulted in EC 50 values ranging from 7.4 to 10.5 mu M, superior to the standard drug benznidazole (EC 50 = 18.7 mu M). Based on these results, it is possible to consider these compounds as scaffolds for the development of new drug candidates against Chagas disease. (AU)

• Processo FAPESP: 23/12447-1 - Busca de metabólitos especializados oriundos da biodiversidade florística brasileira como candidatos a fármacos para doenças tropicais negligenciadas
• Beneficiário: João Henrique Ghilardi Lago
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Regular
• Processo FAPESP: 14/14801-8 - Oxisteróis são capazes de modificar a ubiquitina e comprometer o processo proteolítico ubiquitina proteassoma?
• Beneficiário: Miriam Uemi
• Modalidade de apoio: Auxílio à Pesquisa - Regular