Synthesis of ultrasmall cerium oxide nanoparticles in deep eutectic solvent and their application in an electrochemical sensor to detect dopamine in biological fluid

Autor(es)

Gomes-Junior, Paulo Cardoso ; Longatto, Gustavo Patelli ; Augusto, Karen Kenlderi de Lima ; Rocha, Josias da Silveira ; Piccin, Evandro ; Fatibello-Filho, Orlando

• Tipo de documento: Artigo Científico
• Fonte: Microchimica Acta; v. 191, n. 7, p. 12-pg., 2024-07-01.

Resumo

A solvothermal synthesis of ultrasmall cerium oxide nanoparticles (USCeOxNPs) with an average size of 0.73 +/- 0.07 nm using deep eutectic solvent (DES) as a stabilizing medium at a temperature of 90 degrees C is reported. Transmission electron microscopy (TEM) and energy dispersive spectroscopy (EDS) were used to morphologically characterize the USCeOxNPs. These revealed approximately spherical shapes with emission lines characteristic of cerium. Selected area electron diffraction (SAED) was used to determine the crystalline structure of the cerium oxide nanoparticles (CeO2NPs), revealing the presence of crystalline cubic structures. The USCeOxNPs-DES/CB film was characterized by scanning electron microscopy (SEM), which demonstrated the spherical characteristic of CB with layers slightly covered by DES residues. DES was characterized by Fourier transform infrared (FT-IR) and nuclear magnetic resonance (NMR), indicating its formation through hydrogen bonds between the precursors. An electrochemical sensor for dopamine (DA) determination in biological fluids was developed using the USCeOxNPs together with carbon black (CB). An enhanced current response was observed on DA voltammetric determination, and this can be attributed to the USCeOxNPs. This sensor displayed linear responses for DA in the range 5.0 x 10-7 mol L-1 to 3.2 x 10-4 mol L-1, with a limit of detection of 80 nmol L-1. Besides detectability, excellent performances were verified for repeatability and anti-interference. The sensor based on USCeOxNPs synthesized in DES in a simpler and environmentally friendly way was successfully applied to determine DA in biological matrix. (AU)

• Processo FAPESP: 22/15513-2 - Desenvolvimento de sensores eletroquímicos à base de material carbônico e de nanopartículas metálicas sintetizadas em solventes eutéticos profundos para a determinação de contaminantes emergentes
• Beneficiário: Gustavo Patelli Longatto
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 19/22217-8 - Estudos termoanalíticos aplicados a fármacos antivirais antihepatite e antiretrovirais da classe dos inibidores de protease: comportamento térmico, intermediários de decomposição, caracterização de voláteis e polimorfismo
• Beneficiário: Éder Tadeu Gomes Cavalheiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 24/04116-8 - Emprego de solventes eutéticos profundos em procedimentos espectrofotométricos e eletroanalíticos sustentáveis
• Beneficiário: Orlando Fatibello Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular