Autor(es)

Sbragia, Lourenco ; Gualberto, Igor Jose Nogueira ; Xia, Jason ; Gadde, Rahul ; Saulsbery, Angela ; Hameedi, Sophia ; Dalto, Ana Laura Ferreira Marsico ; Olutoye, Oluyinka O.

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF SURGICAL RESEARCH; v. 303, p. 15-pg., 2024-10-21.

Resumo

Introduction: Necrotizing enterocolitis (NEC) is a severe inflammatory disease of the gastrointestinal tract and one of the most common life-threatening emergencies affecting newborns. Intestinal fatty acid-binding protein (I-FABP) has been used as a possible marker of intestinal damage in NEC. We aimed to carry out a scoping review of all publications that explore the role of I-FABP in NEC to inspire new research into the potential utility of I-FABP as a marker of NEC. Methods: We searched for relevant publications using the keywords "necrotizing enterocolitis," "intestinal fatty acid binding protein," "NEC," and "I-FABP" in the National Library of Medicine (PubMed/MEDLINE), Embase, SCOPUS, and Web of Science. Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews was used for reporting findings. Results: We identified 61 relevant articles, which we divided into clinical (n = 47) and experimental (n = 14) groups. Conclusions: I-FABP is a promising marker of NEC, especially for NEC stage 2 and 3. Urinary I-FABP follows the same patterns as serum and plasma I-FABP. The definitive roles of IFABP in early diagnosis of NEC, differential diagnosis in breast feeding, alimentary intolerance, and screening of surgical NEC need clarification and remain a challenge to investigators. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. (AU)

• Processo FAPESP: 22/12021-1 - Efeito do óxido nítrico inalado na perfusão intestinal no modelo de neonatos de porcos
• Beneficiário: Lourenço Sbragia Neto
• Modalidade de apoio: Bolsas no Exterior - Pesquisa