Autor(es)

Humberto, Janaina Silva Martins ; Saia, Rafael Simone ; Costa, Luis Henrique Angenendt ; Rocha, Maria Jose Alves ; Motta, Ana Carolina Fragoso

• Tipo de documento: Artigo Científico
• Fonte: ODOVTOS INTERNATIONAL JOURNAL OF DENTAL SCIENCES; v. 26, n. 2, p. 13-pg., 2024-05-01.

Resumo

This study aimed to determine salivary concentrations of interleukin (IL)-1 beta, IL-2, IL-10, IL23, transforming growth factor (TGF)- beta, tumor necrosis factor (TNF)- alpha, nitrate (a by-product of nitric oxide oxidation), and cortisol in patients with oral lichen planus (OLP). Twenty patients diagnosed with OLP and 20 sex-matched healthy volunteers (HV) were included in this cross-sectional study. Unstimulated whole saliva was collected in the morning. Salivary cytokine and cortisol concentrations were determined by enzyme-linked immunosorbent assays (ELISA). Nitrate was measured in a nitric oxide analyzer. We found higher salivary concentrations of IL-2 (p<0.003), IL-23 ( p<0.04), and TGF- beta (p=0.05) in patients with OLP compared to HV. No significant differences were found in salivary levels of TNF- alpha, IL-1 beta, or IL-10. Nitrate concentrations were markedly increased in OLP patients (1,227.0 +/- 738.8 mu M/mg total protein) when compared to HV (261.6 +/- 166.8 mu M/mg; p<0.0001). Salivary cortisol levels were also higher in OLP patients (2.79 +/- 1.39 vs. 1.94 +/- 1.21 ng/mg; p<0.048). The markedly increased salivary levels of nitric oxide in patients with OLP suggest a relationship of this molecule with the cell death and tissue damage observed in these lesions. (AU)

• Processo FAPESP: 13/15214-6 - Efeito da colecistocinina na disfunção da barreira epitelial intestinal induzida pela inflamação sistêmica
• Beneficiário: Rafael Simone Saia
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/22183-5 - Aspectos neuroimunoendócrinos em pacientes com diagnóstico de Líquen Plano Oral
• Beneficiário: Karla Karine Duarte Maia
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 14/11883-3 - Perfil clínico, histopatológico e imunopatológico de pacientes com diagnóstico de líquen plano oral
• Beneficiário: Ana Carolina Fragoso Motta
• Modalidade de apoio: Auxílio à Pesquisa - Regular