Autor(es)

Bispo, Henrique Nunes ; Rondon, Eduardo ; dos Santos, Marcelo Rodrigues ; de Souza, Francis Ribeiro ; da Costa, Marcel Jose Andrade ; Pereira, Rosa Maria Rodrigues ; Negrao, Carlos Eduardo ; Carson, Brian P. ; Alves, Maria-janieire de Nazare Nunes ; da Fonseca, Guilherme Wesley Peixoto

• Tipo de documento: Artigo Científico
• Fonte: Journal of Cardiopulmonary Rehabilitation and Prevention; v. 44, n. 4, p. 7-pg., 2024-07-01.

Resumo

Purpose Sarcopenia, the loss of muscle mass and function, is a common comorbidity in patients with heart failure (HF). The skeletal muscle modulates the respiratory response during exercise. However, whether ventilatory behavior is affected by sarcopenia is still unknown. Methods: We enrolled 169 male patients with HF. Muscle strength was measured by a handgrip dynamometer. Body composition was measured with dual-energy X-ray absorptiometry. Sarcopenia was defined by handgrip strength <27 kg and appendicular lean mass divided by height squared (ALM/height(2)) <7.0 kg/m(2). Oxygen uptake efficiency slope (OUES), ventilation (VE), oxygen uptake (VO2), and carbon dioxide output (VCO2) were measured by a cardiopulmonary exercise test. Results: Sarcopenia was identified in 29 patients (17%). At the first ventilatory threshold, VE/VO2 (36.9 +/- 5.9 vs 32.7 +/- 6.5; P = .003) and VE/VCO2 (39.8 +/- 7.2 vs 35.3 +/- 6.9; P = .004) were higher in patients with sarcopenia compared to those without sarcopenia. At the exercise peak, compared to patients without sarcopenia, patients with sarcopenia had lower OUES (1186 +/- 295 vs 1634 +/- 564; P < .001), relative VO2 (16.2 +/- 5.0 vs 19.5 +/- 6.5 mL/kg/min; P = .01), and VE (47.3 +/- 10.1 vs 63.0 +/- 18.2 L/min; P < .0001), while VE/VCO2 (42.9 +/- 8.9 vs 38.7 +/- 8.4; P = .025) was increased. OUES was positively correlated with ALM/height(2) (r = 0.36; P < .0001) and handgrip strength (r = 0.31; P < .001). Hemoglobin (OR = 1.149; 95% CI, 0.842-1.570; P = .038), ALM/height(2) (OR = 2.166; 95% CI, 1.338-3.504; P = .002), and VO2peak (OR = 1.377; 95% CI, 1.218-1.557; P < .001) were independently associated with OUES adjusted by cofounders. Conclusions: Our results suggest that sarcopenia is related to impaired ventilatory response during exercise in patients with HF. (AU)

• Processo FAPESP: 16/24306-0 - O efeito da Neprilisina (LCZ696) sobre a tolerância ao exercício, vasodilatação muscular, força muscular e composição corporal em pacientes com insuficiência cardíaca
• Beneficiário: Marcelo Rodrigues dos Santos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado