Integrated aerobic exercise with LDE-docetaxel treatment: a novel approach to combat prostate cancer progression

Autor(es)

Veras, Allice Santos Cruz ; Batista, Victor Rogerio Garcia ; Correia, Rafael Ribeiro ; Tavares, Maria Eduarda de Almeida ; Rubira, Rafael Jesus Goncalves ; Tavares, Elaine Rufo ; Giometti, Ines Cristina ; Maranhao, Raul Cavalcante ; Teixeira, Giovana Rampazzo

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 14, n. 1, p. 16-pg., 2024-04-26.

Resumo

The variability in response to conventional prostate cancer (PC) therapies, coupled with the emergent issue of drug resistance, underscores the critical need for innovative treatment strategies. Aerobic physical exercise reduced incidence of several cancers, but the mechanism underlying these effects associated the nanoemulsion not fully understood. The application of a lipid nanoemulsion (LDE) delivery system for docetaxel (DTX), showing marked enhancement in therapeutic efficacy when combined with aerobic physical exercise. This novel intervention potentiates the antitumor activity of LDE-delivered DTX by augmenting nanoparticle internalization and inducing cell cycle arrest. Our findings reveal that this synergistic treatment not only significantly reduces prostate weight and mitigates adenocarcinoma proliferation but also attenuates anti-apoptotic BCL-2 protein expression. Concurrently, it elevates pro-apoptotic proteins and diminishes inflammatory markers. Metabolic profiling of the combined therapy group disclosed additional benefits, such as reduced lipid and plasma glucose levels. Collectively, our data illuminate the profound impact of integrating LDE-mediated DTX delivery with structured physical exercise, which together spearhead a dual-front assault on PC. This multimodal approach heralds a new paradigm in PC management, accentuating the promise of combined pharmacological and non-pharmacological interventions to elevate tumor suppressor protein activity and refine patient outcomes. (AU)

• Processo FAPESP: 20/15324-0 - Efeitos do treinamento físico intervalado de alta intensidade (HIIT) nos parâmetros histológicos, bioquimicos e moleculares da bexiga urinaria de ratos espontaneamente hipertensos (SHR)
• Beneficiário: Victor Rogério Garcia Batista
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 20/16310-2 - Desenvolvimento de biotecnologia aplicada a carcinomatose prostática com utilização de nanopartículas carreadores de quimioterápico Docetaxel associado a treinamento físico aeróbico
• Beneficiário: Giovana Rampazzo Teixeira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 20/16166-9 - Desenvolvimento da biotecnologia aplicada ao carcinoma prostático com a utilização de nanopartículas carreadoras do quimioterápico docetaxel associado a treinamento físico aeróbio
• Beneficiário: Allice Santos Cruz Veras
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 21/14514-2 - Análise da caquexia do câncer associado ao tratamento de nanopartículas carreadoras de quimioterápicos docetaxel e metotrexato em ratos sprangue-dawley submetidos ao treinamento físico aeróbio
• Beneficiário: Rafael Ribeiro Correia
• Modalidade de apoio: Bolsas no Brasil - Mestrado