| Texto completo | |
| Autor(es): |
Faria, Alessandra V. S.
;
Andrade, Sheila Siqueira
Número total de Autores: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BIOGERONTOLOGY; v. 26, n. 1, p. 21-pg., 2025-02-01. |
| Resumo | |
The integumentary system serves as a crucial protective barrier and is subject to complex signaling pathways that regulate its physiological functions. As the body's first line of defense, the skin is continuously exposed to environmental stressors, necessitating a robust network of signaling molecules to maintain homeostasis. Considering the main cellular components to be keratinocytes, melanocytes, fibroblasts, and fibrous components, collagen of various types, this review explores the intricate signaling mechanisms that govern skin integrity, focusing on key pathways involved in impacts of ageing and environment factors on skin health. The role of growth factors, cytokines, hormones and other molecular mediators in these processes is examined. Specially for women, decrease of estrogen is determinant to alter signaling and to compromise skin structure, especially the dermis. Environmental factors, such as ultraviolet rays and pollution alongside the impact of ageing on signaling pathways, especially TGF-beta and proteases (metalloproteinases and cathepsins). Furthermore, with advancing age, the skin's capacity to shelter microbiome challenges diminishes, leading to alterations in signal transduction and subsequent functional decline. Understanding these age-related changes is essential for developing targeted therapies aimed at enhancing skin health and resilience, but also offers a promising avenue for the treatment of skin disorders and the promotion of healthy ageing. (AU) | |
| Processo FAPESP: | 16/14459-3 - Lisado plaquetário humano: do descarte a produtos de alto valor agregado direcionados à terapia celular e à medicina moderna |
| Beneficiário: | Sheila Siqueira Andrade |
| Modalidade de apoio: | Auxílio à Pesquisa - Pesquisa Inovativa em Pequenas Empresas - PIPE |
| Processo FAPESP: | 17/26317-1 - InGrowth, produto biomimético desenvolvido por plataforma de bioativação plaquetária: aplicações nas áreas veterinária e pesquisa e desenvolvimento |
| Beneficiário: | Sheila Siqueira Andrade |
| Modalidade de apoio: | Auxílio à Pesquisa - Pesquisa Inovativa em Pequenas Empresas - PIPE |
| Processo FAPESP: | 21/05454-6 - Concepção do PepROBÔ titã: sistema instrutivo de liberação trifásica de ativos |
| Beneficiário: | Rodrigo da Silva Ferreira |
| Modalidade de apoio: | Auxílio à Pesquisa - Pesquisa Inovativa em Pequenas Empresas - PIPE |