| Texto completo | |
| Autor(es): |
de Oliveira, Pamella C. O.
;
Tinoco, Luzineide W.
;
Cardoso, Carmen L.
;
Cass, Quezia B.
;
de Moraes, Marcela C.
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | TRAC-TRENDS IN ANALYTICAL CHEMISTRY; v. 168, p. 8-pg., 2023-10-12. |
| Resumo | |
Acetylcholinesterase and butyrylcholinesterase are the two enzymes involved in the cholinergic system and its modulation. These enzymes have been recognized as therapeutic targets for certain disease states. This article presents a critical overview of both functional and non-functional assays employed in the identification of cholinesterase ligands. Various approaches, including colorimetric assays, zonal and frontal bioaffinity liquid chromatography, affinity selection mass spectrometry, and nuclear magnetic resonance, are discussed. Furthermore, the most innovative and recent applications in drug discovery involving synthetic and natural li-braries are highlighted. (AU) | |
| Processo FAPESP: | 22/00432-7 - Plataformas integradas para triagem de ligantes de enzimas: do desenvolvimento à aplicação |
| Beneficiário: | Carmen Lúcia Cardoso |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |