| Texto completo | |
| Autor(es): |
Monteiro, Juliana C.
[1]
;
Gomes, Marcos L. M.
[2]
;
Tomiosso, Tatiana C.
[3]
;
Nakagaki, Wilson R.
[2]
;
Sbervelheri, Mariana M.
[2]
;
Ferrucci, Danilo L.
[4]
;
Pimentel, Edson R.
[2]
;
Dolder, Heidi
[2]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Fed Espirito Santo, Dept Ciencias Agr & Biol, Ctr Univ Norte Espirito Santo, BR-29932540 Sao Mateus, ES - Brazil
[2] Univ Estadual Campinas, Dept Biol Estrutural & Func, Inst Biol, BR-13083863 Campinas, SP - Brazil
[3] Univ Fed Uberlandia, Dept Histol, Inst Ciencias Biomed, BR-38400902 Uberlandia, MG - Brazil
[4] Univ Estadual Campinas, Dept Bioquim, Inst Biol, BR-13083863 Campinas, SP - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE; v. 11, JUN 28 2011. |
| Citações Web of Science: | 7 |
| Resumo | |
Background: Popular Brazilian medicine uses Heteropterys aphrodisiaca infusion as a tonic or stimulant, for the treatment of nervous debility and breakdown and for muscle and bone weakness. This study investigated the effects of Heteropterys aphrodisiaca infusion on the tendon properties and extracellular matrix of rats under endurance training. Methods: Wistar rats were grouped as follows: CS-control sedentary, HS- H. aphrodisiaca sedentary, CT-control trained, HT-H. aphrodisiaca trained. The training protocol consisted in running on a motorized treadmill, five times a week, with weekly increase in treadmill speed and duration. Control groups received water while the HS and HT groups received H. aphrodisiaca infusion, daily, by gavage for the 8 weeks of training. Achilles tendons were frozen for biochemical and biomechanical analysis or preserved in Karnovsky's fixative, then processed for histomorphological analysis with light microscopy. Results: Biomechanical analysis showed significant increase in maximum load, maximum stress, modulus of elasticity and stiffness of the HT animals' tendons. The metalloproteinase-2 activity was reduced in the HT group. The compression region of HT animals' tendons had a stronger and more intense metachromasy, which suggests an increase in glycosaminoglycan concentration in this region of the tendon. The most intense birefringence was observed in both compression and tension regions of HT animals' tendons, which may indicate a higher organizational level of collagen bundles. The hydroxyproline content increased in the HT group. Conclusions: The association of endurance training with H. aphrodisiaca resulted in more organized collagen bundles and more resistant tendons to support higher loads from intense muscle contraction. Despite the clear anabolic effects of Heteropterys aphrodisiaca and the endurance exercise association, no side effects were observed, such as those found for synthetic anabolic androgenic steroids. (AU) | |
| Processo FAPESP: | 08/05610-3 - A administração da infusão de Heteropterys aphrodisiaca pode ter um efeito anabolizante em ratos submetidos a treinamento físico? |
| Beneficiário: | Mary Anne Heidi Dolder |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 06/06132-2 - Efeito anabolizante da infusão de nó-de-cachorro (Heteropterys aphrodisiaca) associada ao exercício físico em ratos Wistar: análise do sistema músculo esquelético e coração |
| Beneficiário: | Juliana Castro Monteiro |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |