Intraoral Lymphomatoid Papulosis Type D Showing Scarce/Absent CD30 Expression in A Pediatric Patient: Case Report and Literature Review

Autor(es)

Palacon, Mariana Paravani ; Marques, Marcelo Borges ; Silveira, Debora Fernandes Mendes ; Martins, Karina Helen ; Silveira, Heitor Albergoni ; Pereira-Filho, Valfrido Antonio ; Bufalino, Andreia ; Chahud, Fernando ; Leon, Jorge Esquiche

• Tipo de documento: Artigo Científico
• Fonte: Head and Neck Pathology; v. 19, n. 1, p. 5-pg., 2025-02-05.

Resumo

Purpose Approximately 10% of all lymphomatoid papulosis (LyP) cases affect pediatric patients. Pediatric LyP is clinically similar to adult LyP, frequently with cutaneous involvement, whereas the affectation of mucosal surface is rare. The LyP clinicopathological spectrum includes type A, B, C, D, E, and LyP with DUSP22/IRF4 rearrangement, with LyP type D representing < 5% of all LyP cases. Methods We have previously reported 2 cases of exclusively intraoral LyP type C and E. To date, about 50 cases of LyP type D have been reported; of them, 8 cases, all but one with exclusive skin involvement, corresponded to pediatric patients. Rare LyP type C cases can lack CD30 expression, creating diagnostic difficulties with lymphoma. Results Here, we report an extremely rare case of intraoral LyP type D with scarce/absent CD30 expression affecting a 12-year-old white Brazilian boy. Conclusions To our best knowledge, this is the first pediatric case of LyP type D with exclusive intraoral involvement. (AU)

• Processo FAPESP: 16/11419-0 - Correlação clinicopatológica do grau de diferenciação, expressão de tetraspaninas, agentes virais e proliferação celular em uma ampla série de carcinomas espinocelulares da região de cabeça e pescoço.
• Beneficiário: Jorge Esquiche León
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 22/12760-9 - Correlação clinicopatológica do sistema imune, diferenciação celular, angiogênese, metabolismo lipídico e HPV transcricionalmente ativo em uma ampla série de carcinomas espinocelulares da região de cabeça e pescoço
• Beneficiário: Jorge Esquiche León
• Modalidade de apoio: Auxílio à Pesquisa - Regular