Carbon dioxide redox metabolites in oxidative eustress and oxidative distress

Autor(es)

Augusto, Ohara ; Truzzi, Daniela Ramos

• Tipo de documento: Artigo Científico
• Fonte: BIOPHYSICAL REVIEWS; v. 13, n. 6, p. 3-pg., 2021-12-01.

Resumo

High carbon dioxide tensions (hypercapnia) are toxic to mammals by both pH-dependent and pH-independent mechanisms that remain partially understood. Relevantly, carbon dioxide reacts with biologically ubiquitous oxygen metabolites such as peroxynitrite and hydrogen peroxide to produce carbonate radical and peroxymonocarbonate, respectively. These metabolites are redox active making it timely to discuss the potential role of carbon dioxide redox metabolites in oxidative eustress and oxidative distress conditions. (AU)

• Processo FAPESP: 19/17483-0 - Dinitrosilos complexos de ferro (DNICs): formação, reatividade e implicações para a fisiopatologia do óxido nítrico
• Beneficiário: Daniela Ramos Truzzi
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 13/07937-8 - Redoxoma
• Beneficiário: Ohara Augusto
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs