Functionalization of bacterial nanocellulose-based wound dressing for increased drug retention

Autor(es)

Breijaert, Troy C. ; Fontes, Marina ; Fernandes, Paula de Abreu ; Barud, Hernane da Silva ; Ribeiro, Sidney J. L. ; Seisenbaeva, Gulaim A.

• Tipo de documento: Artigo Científico
• Fonte: CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS; v. 10, p. 14-pg., 2025-06-01.

Resumo

Bacterial nanocellulose is a fascinating biopolymer with immense application potential, including as a wound dressing material. It is highly biocompatible and capable of keeping humidity needed for wound healing. However, it lacks specific affinity to pharmaceuticals to be delivered in a controlled fashion in a topical application, urged by the necessity to decrease the release of medicines to the environment. Solving this problem requires tailoring of the material functionality by chemical modification. In this work, a two-step strategy applying first phosphorylation and then introduction of biocompatible mineral particles was applied. Surface modification of commercially available wound dressing material based on dried bacterial nanocellulose led to phosphate grafting of 1.5-1.8 mmol/g and then uniform coverage of individual fibers (colloidal TiO2) or formation of aggregated platelets (TiBALDH (R)) on the surface (with Ti:P element ratios 0.45-0.80). To the titania functionalized dressing the broad spectrum antibiotic Tetracycline was bound (41-45 mg g-1) with its release delayed over several hours / days (over 50 % in 120 h for both nanocarriers). Biological essays indicated excellent biocompatibility and improved cell adhesion, offering a path to accelerated wound closure, promising for diverse tissue engineering applications. This study demonstrated a strategy in approach to dressing materials with delayed drug release properties exploiting the affinity of pharmaceuticals to mineral nanoparticles. (AU)

• Processo FAPESP: 21/11965-3 - Centro de manejo sustentável de pragas doenças e plantas daninhas
• Beneficiário: Mário Eidi Sato
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Ciência para o Desenvolvimento
• Processo FAPESP: 17/50334-3 - Plano de Desenvolvimento Institucional em Pesquisa (PDIp): modernização e adequação de unidades multiusuárias estratégicas do Instituto Biológico
• Beneficiário: Ana Eugênia de Carvalho Campos
• Modalidade de apoio: Auxílio à Pesquisa - Programa Modernização de Institutos Estaduais de Pesquisa
• Processo FAPESP: 23/17580-1 - Desenvolvimento de novas plataformas celulares baseadas em celulose bacteriana conjugada a peptídeos: avaliação da bioatividade e promoção da adesão/proliferação celular.
• Beneficiário: Paula de Abreu Fernandes
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 23/10811-8 - Desenvolvimento de aptassensor baseado em polímeros recicláveis/biodegradáveis para a detecção de três principais sorotipos de Salmonella
• Beneficiário: Marina de Lima Fontes
• Modalidade de apoio: Bolsas no Brasil - Programa Fixação de Jovens Doutores