Exploring the dual role of SIVA1 in cancer biology

Autor(es)

Parducci, Natalia Sudan ; Garnique, Anali Del Milagro Bernabe ; de Almeida, Bruna Oliveira ; Machado-Neto, Joa Agostinho

• Tipo de documento: Artigo Científico
• Fonte: Gene; v. 950, p. 9-pg., 2025-03-03.

Resumo

The intricate molecular mechanisms associated with cancer development continue to engage researchers due to the significant impact of the disease on global mortality. This review delves into the role of the apoptosis regulatory protein SIVA1, which has emerged as a significant player in cellular homeostasis. SIVA1, initially characterized as a pro-apoptotic protein interacting with the TNF receptor CD27, has since been implicated in various cellular contexts, revealing its complex functional dynamics. The SIVA1 gene, located on chromosome 14, encodes a protein containing distinctive structural features, including an amphipathic helix and a death domain homology region. Localization studies show that SIVA1 is present in both the cytoplasm and nucleus, with its expression linked to tumor differentiation. Investigations into SIVA1 ' s interactions have uncovered its pro-apoptotic mechanisms, such as binding to anti-apoptotic proteins from the BCL2 family, thus promoting apoptosis under stress conditions. Interestingly, SIVA1 also exhibits tumor-promoting properties in specific cancer types, suggesting a dual role in apoptosis induction and tumor progression. As research progresses, understanding the regulatory mechanisms governing SIVA1 ' s multifaceted functions could pave the way for novel therapeutic strategies aimed at manipulating its activity for improved cancer treatment outcomes. Future studies are warranted to clarify SIVA1 ' s contextual roles and explore its potential clinical implications. (AU)

• Processo FAPESP: 23/11752-5 - Avaliação da função de SIVA1 na malignidade e invasividade de modelos de câncer de mama
• Beneficiário: Natália Sudan Parducci
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 22/11038-8 - Investigação de vias de sinalização e processos biológicos associados à proteína ANKHD1 em Câncer de Estômago
• Beneficiário: Bruna Oliveira de Almeida
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto