| Texto completo | |
| Autor(es): |
Bombarda, Thais R.
;
Fontes, Marina L.
;
Sabio, Rafael
;
Meneguin, Andreia
;
Surur, Amanda
;
Fontana, Carla Raquel
;
Lustri, Wilton
;
Fregonezi, Nathalia
;
Nogueira, Flavia
;
Barud, Hernane S.
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of the Brazilian Chemical Society; v. 36, n. 7, p. 12-pg., 2025-01-01. |
| Resumo | |
Regenerated cellulose sponge (RCS) holds significant promise for biomedical applications due to its biocompatibility, flexibility, and porosity. Silver nanoparticles (AgNPs) were synthesized via hydrothermal reduction of silver nitrate (AgNO3) at three concentrations and incorporated into the RCS matrix. RCS@AgNPs biocomposites were characterized through morphological, physicochemical, and biological assays. Field emission gun scanning electron microscopy (FEG-SEM) revealed a rough, porous sponge surface with square AgNPs (49-84 nm) and minimal agglomeration, suggesting the role of RCS as a reducing and stabilizing material. The attenuation of the band at 3300 cm(-1) indicated interactions between RCS hydroxyl groups and AgNPs through hydrogen bonding. Indeed, AgNPs enhanced the thermal stability of RCS@AgNPs by increasing its maximum decomposition temperature. Pristine RCS exhibited a superior liquid uptake capacity (953% of its weight in ca. 5 min), while RCS@AgNPs biocomposites showed varying liquid uptake profiles (610-800%). Cytotoxicity and microbiological assays confirmed the biocompatibility and antimicrobial activity of RCS@AgNPs against Grampositive and Gram-negative bacteria, highlighting their potential for tissue engineering. (AU) | |
| Processo FAPESP: | 18/25377-3 - Avaliação do potencial de nanopartículas de sílica mesoporosas funcionalizadas com cetuximabe para veiculação de docetaxel no tratamento do câncer de próstata. |
| Beneficiário: | Rafael Miguel Sábio |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |