Living high-training low model promotes increased spontaneous physical activity, reduced adiposity and maintenance of fat-free mass in C57BL/6J mice

Autor(es)

Orsi, Juan B. ; Scariot, Pedro P. M. ; Polisel, Emanuel E. C. ; Araujo, Lara S. ; Santos, Matheus R. ; Papoti, Marcelo ; Manchado-Gobatto, Fulvia B. ; Gobatto, Claudio A.

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY; v. N/A, p. 14-pg., 2025-06-06.

Resumo

Researchers have extensively studied how hypoxia affects physiological variables, with training models like "live high - train low" (LH-TL) proposed by Levine & Stray-Gundersen in 1997 to improve athletic performance. Although well-known, few studies use animal models for more in-depth analyses than human studies allow. This study investigated the effects of aerobic training on adiposity, spontaneous physical activity (SPA), and food and water intake in C57BL/6J mice housed in normoxic (Nx) or hypoxic (Hx) conditions for 8 weeks. Mice were divided into trained (T) and sedentary (S) groups, with 10 mice each. Hx animals were kept in normobaric hypoxia (FiO2=14.5%) for 18 h/day. Training was done at 80% critical velocity, 5 times/week in normoxia. The T groups had lower SPA, especially the Hx-T group, which showed higher food and water intake, reduced fat, and a higher fat-free mass/carcass fat mass ratio. Findings suggest exercise and hypoxia may help combat obesity. (AU)

• Processo FAPESP: 24/04688-1 - Efeitos do modelo de treinamento "viver alto - treinar baixo" sobre respostas hematimétricas, biomoleculares e bioquímicas associadas ao balanço energético
• Beneficiário: Juan Bordon Orsi
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 19/05115-7 - Efeitos do treinamento aeróbio e do ambiente em hipóxia sobre respostas moleculares envolvidas com o metabolismo anaeróbio, aeróbio e controle ácido-básico nos tecidos hipotalâmico e muscular de camundongos
• Beneficiário: Pedro Paulo Menezes Scariot
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/10201-4 - Efeitos do treinamento físico aeróbio e espaço habitacional de camundongos sobre a atividade física espontânea e respostas metabólicas e moleculares centrais e periféricas.
• Beneficiário: Claudio Alexandre Gobatto
• Modalidade de apoio: Auxílio à Pesquisa - Regular