Transition Metal-Promoted Direct C-S and C-Se Bond Formation from Csp³-H Bonds

Autor(es)

Paixao, Douglas B. ; Seckler, Diego ; Gomes, Carla M. B. ; Badshah, Gul ; Bueno, Gabriel P. ; Schneider, Paulo H. ; Schwab, Ricardo S. ; Rampon, Daniel S.

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY; v. 28, n. 20, p. 27-pg., 2025-05-02.

Resumo

The transition metal-catalyzed direct C-S and C-Se bond formation from C-H bonds has emerged as an efficient synthetic strategy for constructing previously inaccessible organochalcogen compounds, opening a new gateway to late-stage functionalization of pharmaceutical-relevant molecules and organic functional materials. C-Y bonds (Y=S, Se, Te) also show outstanding strategic relevance as handles to access other valuable functional groups downstream in a synthetic route. Despite the significant progress, the chemo-, site-, and enantioselective C-S and C-Se bond formation from unactivated Csp(3)-H bonds is still challenging owing to its low polarity and inertness. Here, a comprehensive overview of the transition metal-catalyzed direct conversion of unactivated Csp(3)-H to C-S and C-Se bonds in the last decade is provided, looking to motivate the continuous discovery of innovative and efficient systems for these transformations. (AU)

• Processo FAPESP: 21/12394-0 - Métodos sintéticos sustentáveis empregando catálise, solventes verdes, reagentes seguros e materiais de partida renováveis
• Beneficiário: Arlene Gonçalves Corrêa
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/06558-3 - Catálise metálica assimétrica: preparação de alcoóis quirais e seus derivados a partir de reagentes orgânicos de zinco poli-funcionalizados e aplicação de novos ligantes quirais suportados em nanopartículas magnéticas
• Beneficiário: Ricardo Samuel Schwab
• Modalidade de apoio: Auxílio à Pesquisa - Regular