Ag Nanoparticles/α-Ag₂WO₄ Composite Formed by Electron Beam and Femtosecond Irradiation as Potent Antifungal and Antitumor Agents

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Assisi, M. ; Robeldo, T. ; Foggi, C. C. ; Kubo, A. M. ; Minguez-Vega, G. ; Condoncillo, E. ; Beltran-Mir, H. ; Torres-Mendieta, R. ; Andres, J. ; Oliva, M. ; Vergani, C. E. ; Barbugli, P. A. ; Camargo, E. R. ; Borra, R. C. ; Longo, E.

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 9, p. 15-pg., 2019-07-09.

Resumo

The ability to manipulate the structure and function of promising systems via external stimuli is emerging with the development of reconfigurable and programmable multifunctional materials. Increasing antifungal and antitumor activity requires novel, effective treatments to be diligently sought. In this work, the synthesis, characterization, and in vitro biological screening of pure alpha-Ag2WO4, irradiated with electrons and with non-focused and focused femtosecond laser beams are reported. We demonstrate, for the first time, that Ag nanoparticles/alpha-Ag2WO4 composite displays potent antifungal and antitumor activity. This composite had an extreme low inhibition concentration against Candida albicans, cause the modulation of alpha-Ag2WO4 perform the fungicidal activity more efficient. For tumor activity, it was found that the composite showed a high selectivity against the cancer cells (MB49), thus depleting the populations of cancer cells by necrosis and apoptosis, without the healthy cells (BALB/3T3) being affected. (AU)

• Processo FAPESP: 13/07296-2 - CDMF - Centro de Desenvolvimento de Materiais Funcionais
• Beneficiário: Elson Longo da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 13/26671-9 - Estudo teórico-experimental de semicondutores multifuncionais
• Beneficiário: Amanda Fernandes Gouveia
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/12594-3 - CDMF - Centro de Desenvolvimento de Materiais Funcionais
• Beneficiário: Camila Cristina de Foggi
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado