Autor(es)

Bombassaro, Bruna ; Batitucci, Gabriela ; Simoes, Marcela Reymond ; Araujo, Eliana P. ; Velloso, Licio A.

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN NUTRITION; v. 12, p. 14-pg., 2025-08-04.

Resumo

The development of strategies that promote the activation of adaptive thermogenesis in brown and beige adipose tissues is expected to lead to advances in the prevention and treatment of obesity, diabetes, and cardiovascular diseases. Currently, there is a great effort to identify or develop pharmacological agents that could promote adaptive thermogenesis. However, the greatest candidates, the beta 3-adrenergic receptor agonists, have proven troublesome as they promote unwanted cardiovascular effects. An important advance in the field of adaptive thermogenesis was made by the identification of nutrients or nutrient-derived substances that activate thermogenesis in brown and beige adipose tissue. The detailed characterization of the mechanisms by which nutrients activate thermogenesis could lead to changes in the nutritional guidelines for metabolic diseases. In addition, these studies could unveil new targets for the development of pharmacological strategies to treat metabolic and cardiovascular diseases. In this article, we review the data that led to the current understanding of the actions of nutrients or nutrient-derived substances as thermogenic agents. (AU)

• Processo FAPESP: 13/07607-8 - CMPO - Centro Multidisciplinar de Pesquisa em Obesidade e Doenças Associadas
• Beneficiário: Licio Augusto Velloso
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs