Autor(es)

Ferreira, Mariana Almeida ; Vargas, Gabrielle Silveira ; Barbosa, Joao Vitor Gregolan ; Castilho, Allana de Paula ; Leite, Ingrid Goncalves Costa ; dos Santos, Jandra Pacheco ; Miguel, Marina Pacheco ; Cocio, Tiago Alexandre ; de Freitas-Xavier, Roseli Santos ; Ferreira Junior, Alvaro

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Microbiology; v. N/A, p. 12-pg., 2025-08-24.

Resumo

We report the first case of phaeohyphomycosis caused by the dematiaceous dimorphic fungus Exophiala spinifera in a free-roaming domestic cat from the Americas, specifically diagnosed in the Central-West Region of Brazil, which progressed to euthanasia due to severe clinical deterioration. A comprehensive diagnostic approach was employed, integrating epidemiological, clinical, laboratory, mycological, and molecular analyses to confirm the fungal infection. In addition to the fungal infection, the cat tested seropositive for feline immunodeficiency virus (FIV) and was suspected of having seromucous adenocarcinoma. The response of E. spinifera to itraconazole (ITZ) therapy and the post-mortem findings are also presented. This case highlights the importance of considering Exophiala species in the differential diagnosis of fungal infections in animals. The findings contribute to a better understanding of the clinical presentation, diagnosis, and potential ecological implications of E. spinifera, offering valuable insights for veterinarians, researchers, and clinicians involved in the management of zoonotic mycoses. (AU)

• Processo FAPESP: 22/14747-0 - Epidemiologia molecular e mecanismo de resistência a azólicos em aspergillus spp.: estudo de isolados de aspergilose pulmonar crônica pós-tb e invasiva aguda em duas regiões do estado de são paulo.
• Beneficiário: Tiago Alexandre Cocio
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado