| Texto completo | |
| Autor(es): Mostrar menos - |
Siqueira, Victor da Silva
;
Reis, Thais Santos Anjo
;
Ferreira, Stefanne Rodrigues Rezende
;
Rodrigues, Sarah Gomes
;
Rodrigues Junior, Benilton Alves
;
Fleury, Amanda Cristina Correa
;
da Silva, Claudinei Alves
;
Nebo, Liliane
;
Barbieri, Hellen Bertoletti
;
Barbosa, Julio Cesar Jeronimo
;
Cardoso, Ludimila Paula Vaz
;
Siqueira, Carla Silva
;
Rezende, Hanstter Hallison Alves
Número total de Autores: 13
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Experimental Parasitology; v. 278, p. 12-pg., 2025-11-01. |
| Resumo | |
Toxoplasmosis, caused by the protozoan Toxoplasma gondii, typically manifests asymptomatically in immunocompetent individuals, leading to persistent chronic infection. However, immunosuppressed patients, such as transplant recipients, often develop neurotoxoplasmosis. The most commonly used therapy for neurotoxoplasmosis involves a combination of sulfadiazine, pyrimethamine, and folinic acid, but this treatment is associated with numerous side effects, leading to high rates of discontinuation. Ethanolic extract (EE) and alpha-bisabolol derived from the Siparuna guianensis plant have demonstrated favorable potential as a therapeutic alternative to parasitic diseases. Therefore, this study is aimed to evaluate the antitoxoplasmic potential of the ethanolic extract and the isolated alpha-bisabolol from S. guianensis in the treatment of in vivo neurotoxoplasmosis in Swiss mice. After 14 days of treatment, the mice were euthanized and their blood, brain, liver and kidney were collected for analysis. Histopathological analysis of the brain revealed that treatment with EE at a concentration of 200 mg/kg/day resulted in a lower parasite burden. Biochemical and histopathological analysis of the livers and kidneys indicated low liver and kidney toxicity of EE. Based on these results, it is concluded that EE at a concentration of 200 mg/kg/day was more effective in controlling T. gondii, being able to cross the blood-brain barrier, as well as being less toxic to the host, showing an action similar to conventional treatment. (AU) | |
| Processo FAPESP: | 22/02992-0 - Decifrando o papel de metabólitos secundários na interação química entre fitopatógenos e o hospedeiro citros |
| Beneficiário: | Taicia Pacheco Fill |
| Modalidade de apoio: | Auxílio à Pesquisa - Projeto Inicial |