| Texto completo | |
| Autor(es): |
Bassetto, Cesar Cristiano
;
de Albuquerque, Ana Claudia Alexandre
;
Lins, Jose Gabriel Goncalves
;
Canalli, Guilherme Fernandes Dias
;
Gomes, Anandra Kauara dos Santos
;
Amarante, Alessandro Francisco Talamini
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PATHOGENS; v. 14, n. 11, p. 14-pg., 2025-10-22. |
| Resumo | |
The intensity and prevalence of different gastrointestinal nematode species vary across regions worldwide. Oesophagostomum radiatum commonly shows a high occurrence in young cattle. O. radiatum causes anaemia, hypoproteinaemia, and immunopathological changes in the large intestine wall, impairing calves' body weight gain. This study aimed to assess the impact of natural O. radiatum infection on haematological parameters and immune responses in 23 Nellore calves, considering sex-based differences. Assessments included Oesophagostomum egg count (EPG), worm count, packed cell volume (PCV), total plasma protein, histopathological and immunohistochemistry analyses. A large number of parasites attached to the colon mucosa were observed, along with massive nodule formation and haemorrhagic lesions, mainly within a 20-30 cm-long segment adjacent to the nodules. The maximum mean egg shedding was approximately 165 EPG for males and 173 EPG for female calves; however, males presented a significantly higher worm count (969 +/- 200.5) than females (460 +/- 99.5). There were significant positive correlations between the total O. radiatum worm count and O. radiatum EPG for both female and male calves. Significant negative correlations were observed between the total O. radiatum worm count and PCV in female calves. Our results demonstrated that natural O. radiatum infection in Nellore calves induced marked immunopathological alterations, including chronic inflammatory responses that impaired intestinal function. Sex-related differences suggested that female calves may develop more effective tissue responses. These findings emphasise the economic impact of subclinical infections and reinforce the importance of control strategies to minimise productivity losses in cattle. (AU) | |
| Processo FAPESP: | 10/18678-5 - Proteção de ovinos e bovinos contra haemoncose após imunização com antígenos oriundos da membrana intestinal de Haemonchus contortus. |
| Beneficiário: | César Cristiano Bassetto |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 25/13075-6 - Diferenças na resposta imune de cordeiros Santa Inês à infecção por Haemonchus contortus |
| Beneficiário: | Guilherme Fernandes Dias Canalli |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 24/02589-6 - Perfil transcriptômico e celular da resposta imune local frente à infecção artificial por Haemonchus contortus em cordeiros de diferentes raças e fenótipos de resistência |
| Beneficiário: | Ana Claudia Alexandre de Albuquerque |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |