| Texto completo | |
| Autor(es): |
Siden-Kiamos, Inga
;
Goosmann, Christian
;
Buscaglia, Carlos A.
;
Brinkmann, Volker
;
Matuschewski, Kai
;
Montagna, Georgina N.
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Molecular and Biochemical Parasitology; v. 235, p. 4-pg., 2020-01-01. |
| Resumo | |
Gliding motility and cell invasion are essential for the successful transmission of Plasmodium parasites. These processes rely on an acto-myosin motor located underneath the parasite plasma membrane. The Myosin A-tail interacting protein (MTIP) connects the class XIV myosin A (MyoA) to the gliding-associated proteins and is essential for assembly of the motor at the inner membrane complex. Here, we assessed the subcellular localization of MTIP in Plasmodium berghei motile stages from wild-type parasites and mutants that lack MyoA or the small heat shock protein 20 (HSP20). We demonstrate that MTIP is recruited to the apical end of motile ookinetes independently of the presence of MyoA. We also show that infective sporozoites displayed a polarized MTIP distribution during gliding, and that this distribution was abrogated in mutant parasites with an aberrant locomotion. (AU) | |
| Processo FAPESP: | 14/07138-0 - Estudo da motilidade do parasita Plasmodium: identificação de novas moléculas alvo de terapia e validação de candidatos a vacina |
| Beneficiário: | Georgina Nuri Montagna |
| Modalidade de apoio: | Bolsas no Brasil - Jovens Pesquisadores |
| Processo FAPESP: | 13/14361-5 - Estudo da motilidade do parasita Plasmodium: identificação de novas moléculas alvo de terapia e validação de candidatos a vacina |
| Beneficiário: | Georgina Nuri Montagna |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |