| Texto completo | |
| Autor(es): |
Rengifo, Andres Vicent Cubas
;
Rivadeneyra Sanchez, Norma Lorena
;
Teixeira, Chloe Barbosa
;
Madrid, Rafael R. M.
;
Mertins, Omar
;
Mathews, Patrick D.
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 27, n. 2, p. 16-pg., 2026-01-19. |
| Resumo | |
Monogenean parasite infestation in fish leads to economic losses in aquaculture, representing a veterinary challenge and an environmental concern. The common administration procedures of anthelmintics to treat monogeneans in fish have low efficiency and diverse drawbacks. In this study, we produced a nanoparticle using chitosan and alginate, biodegradable and biocompatible polysaccharides, as an oral drug delivery material of albendazole anthelmintic for parasite-infected fingerlings of Nile tilapia. The molecular interaction between the biopolymers was optimized and characterized by titration calorimetry. Freeze-drying of nanoparticles resulted in a fine powder with a particle size in the order of 400 nm. The nanoparticles provided 98% encapsulation of albendazole and sustained delivery with predominantly Fickian diffusion. The palatability of the nanoparticle formulation facilitated the oral administration of albendazole. The treatment of 100% prevalence of monogeneans was effective with a six-day dosage providing a total of 915 mg/kg b.w. of drug, resulting in total parasite clearance after 10 days from the treatment beginning, evidenced by microscopy analysis, and no mortality occurred. Therefore, molecular interactions between biofriendly polyelectrolytes yielded albendazole-carrying nanoparticles for high-efficiency parasite treatment in fish farming. (AU) | |
| Processo FAPESP: | 22/12376-4 - Desenvolvimento de tratamento parasitário em peixes com nanopartículas: uma abordagem tecnológico-aplicativa |
| Beneficiário: | Patrick Mathews Delgado |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |