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do Nascimento, Mariah Cristina Antunes
;
Galbiatti-Dias, Ana Livia Silva
;
Figueiredo, Lucas Brumato
;
Marzochi, Ludimila Leite
;
Castanhole-Nunes, Marcia Maria Urbanin
;
Andrade, Rafael Felipe Maciel
;
Maniglia, Jose Victor
;
Castiglioni, Lilian
;
de Oliveira-Cucolo, Juliana Garcia
;
Pavarino, Erika Cristina
;
Goloni-Bertollo, Eny Maria
Número total de Autores: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Brazilian Journal of Otorhinolaryngology; v. 92, n. 2, p. 8-pg., 2026-03-01. |
| Resumo | |
Objectives: Human Papillomavirus (HPV) may be a predictive biomarker predictor for clinical outcome and influence treatment decisions in patients with Head and Neck Squamous Cell Carcinoma (HNSCC). Methods: We evaluated 253 patients with HNSCC from state of Sao Paulo, Brazil. The influence of p16INx4a expression was analyzed with epidemiological and clinical variables. Results: In total, 32.4% of tumors studied had positive (+) p16INx4a protein expression, and 67.6% had negative. The variables were similar in both groups being the mostly with age under 64-years, male, white race, functional illiterate, smokers and alcoholics. The most affected primary site was oral cavity with T3/T4 tumoral stage, N1/ N2/N3 nodals, M0 metastasis and III/IV clinical stage. Patients with oropharyngeal primary site and (+) p16INx4a, clinical staging III and chemotherapy treatment had worse survival. The median time of distant metastasis-free was 38.3-months in oropharyngeal (+) p16INx4a and 15.1-months in negative (-) p16INx4a. Conclusion: In the present study, the epidemiological variables are similar in both groups (Positive and negative p16INx4a expression): age under 64-years, male, white, functionally illiterate, smokers and alcoholics. There is no association of p16INx4a expression with primary site, however, the (-) p16INx4a shows better overall survival, higher frequencies in distant metastasis and less free time of the disease. Although the literature shows a greater survival in oropharynx (+) p16INx4a, our results are contradictory. It is suggested that future studies in different regions and with a larger sample size should be carried out to confirm these findings, because the patients who participated in the present study are only from a specific region of Brazil. Level of evidence: 2B. (AU) | |
| Processo FAPESP: | 18/26166-6 - Biomarcadores e células-tronco tumorais no tratamento do câncer de cabeça e pescoço |
| Beneficiário: | Eny Maria Goloni Bertollo |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |